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Antimicrobial Agents and Chemotherapy, August 2006, p. 2836-2841, Vol. 50, No. 8
0066-4804/06/$08.00+0     doi:10.1128/AAC.00295-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Differential Gene Expression in Response to Exposure to Antimycobacterial Agents and Other Stress Conditions among Seven Mycobacterium tuberculosis whiB-Like Genes

Deborah E. Geiman, Tirumalai R. Raghunand, Nisheeth Agarwal, and William R. Bishai*

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231

Received 8 March 2006/ Returned for modification 12 April 2006/ Accepted 7 June 2006

The seven Mycobacterium tuberculosis whiB-like genes encode small proteins postulated to be transcriptional regulators. A systematic real-time reverse transcription-PCR analysis following exposure to antibiotics and a variety of growth and in vitro stress conditions indicates differential, and in some cases dramatic, transcription modulations for the different M. tuberculosis whiB family members. This information together with biochemical analyses of the whiB1 to whiB7 gene products will be important for understanding the biology of this novel family of proteins in mycobacteria and related actinomycetes.

* Corresponding author. Mailing address: Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, 1550 Orleans Street, Room 1.08, Baltimore, MD 21231. Phone: (410) 955-3507. Fax: (410) 614-8173. E-mail: wbishai{at}jhmi.edu.

Antimicrobial Agents and Chemotherapy, August 2006, p. 2836-2841, Vol. 50, No. 8
0066-4804/06/$08.00+0     doi:10.1128/AAC.00295-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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