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Antimicrobial Agents and Chemotherapy, August 2006, p. 2842-2844, Vol. 50, No. 8
0066-4804/06/$08.00+0     doi:10.1128/AAC.00250-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Moxifloxacin Lethality against Mycobacterium tuberculosis in the Presence and Absence of Chloramphenicol

Muhammad Malik and Karl Drlica*

Public Health Research Institute, 225 Warren Street, Newark, New Jersey 07103

Received 28 February 2006/ Returned for modification 10 May 2006/ Accepted 22 May 2006

The C-8-methoxy fluoroquinolone moxifloxacin was more lethal against chloramphenicol-treated Mycobacterium tuberculosis than Bay y3114, a C-8-H cognate of moxifloxacin, and two C-8-methoxy fluoroquinolones, gatifloxacin and BMS-433368, which have different C-7 substituents. Thus, an optimal combination of C-7 and C-8 substituents is likely to be important for killing nongrowing M. tuberculosis.

* Corresponding author. Mailing address: Public Health Research Institute, 225 Warren Street, Newark, NJ 07103. Phone: (973) 854-3360. Fax: (973) 854-3101. E-mail: drlica{at}phri.org.

Antimicrobial Agents and Chemotherapy, August 2006, p. 2842-2844, Vol. 50, No. 8
0066-4804/06/$08.00+0     doi:10.1128/AAC.00250-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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