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Antimicrobial Agents and Chemotherapy, August 2006, p. 2850-2852, Vol. 50, No. 8
0066-4804/06/$08.00+0     doi:10.1128/AAC.00313-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Inhibition of Plasmodium falciparum Growth In Vitro and Adhesion to Chondroitin-4-Sulfate by the Heparan Sulfate Mimetic PI-88 and Other Sulfated Oligosaccharides

Yvonne Adams,1,2 Craig Freeman,3 Reinhard Schwartz-Albiez,4 Vito Ferro,5 Christopher R. Parish,3 and Katherine T. Andrews2*

Hygiene-Institut, Abteilung Parasitologie, Universität Heidelberg, Im Neuenheimer Feld 324, D-69120 Heidelberg, Germany,1 Clinical Tropical Medicine Laboratory and the Australian Centre for International and Tropical Health and Nutrition (ACITHN), Queensland Institute of Medical Research, QLD 4006, Australia,2 Cancer and Vascular Biology Group, Division of Immunology and Genetics, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia,3 Deutsches Krebsforschungszentrum, Tumorimmunologie, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany,4 Drug Design Group, Progen Industries Ltd., Darra, QLD 4076, Australia5

Received 13 March 2006/ Returned for modification 26 April 2006/ Accepted 2 June 2006

A panel of sulfated oligosaccharides was tested for antimalarial activity and inhibition of adhesion to the placental malaria receptor chondroitin-4-sulfate (CSA). The heparan sulfate mimetic PI-88, currently undergoing phase II anticancer trials, displayed the greatest in vitro antimalarial activity against Plasmodium falciparum (50% inhibitory concentration of 7.4 µM) and demonstrated modest adhesion inhibition to cell surface CSA.

* Corresponding author. Mailing address: Clinical Tropical Medicine Laboratory, Infectious Diseases and Immunology Division, Queensland Institute of Medical Research, Herston, QLD 4029, Australia. Phone: 61 (0)7 3845 3725. Fax: 61 (0)7 3362 0104. E-mail: kathy.andrews{at}qimr.edu.au.

Antimicrobial Agents and Chemotherapy, August 2006, p. 2850-2852, Vol. 50, No. 8
0066-4804/06/$08.00+0     doi:10.1128/AAC.00313-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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