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Antimicrobial Agents and Chemotherapy, August 2006, p. 2860-2862, Vol. 50, No. 8
0066-4804/06/$08.00+0     doi:10.1128/AAC.00303-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Resistance Levels and rpoB Gene Mutations among In Vitro-Selected Rifampin-Resistant Mycobacterium tuberculosis Mutants

Emma Huitric,1,2 Jim Werngren,1,2* Pontus Juréen,1,2 and Sven Hoffner1

Department of Bacteriology, Swedish Institute for Infectious Disease Control Solna, and,1 Department of Microbiology, Tumor and Cell Biology Center, Karolinska Institute, Stockholm, Sweden2

Received 10 March 2006/ Returned for modification 12 April 2006/ Accepted 2 June 2006

The distribution and resistance levels of 189 in vitro-selected rifampin-resistant Mycobacterium tuberculosis mutants of Beijing and other genotypes were determined. Apart from a higher amount of codon 522 point mutations and large deletions, a spread of mutations similar to that reported for clinical isolates was seen. Most mutations were correlated with high-level resistance; a lower level, or a MIC of <16 mg/liter, was associated with codon 522 mutations. Multiple mutations were detected in two Beijing mutants.

* Corresponding author. Mailing address: Department of Bacteriology, Swedish Institute for Infectious Disease Control, S-171 82 Solna, Sweden. Phone: 46 8 4572473. Fax: 46 8 301797. E-mail: jim.werngren{at}smi.ki.se.

Antimicrobial Agents and Chemotherapy, August 2006, p. 2860-2862, Vol. 50, No. 8
0066-4804/06/$08.00+0     doi:10.1128/AAC.00303-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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