This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Robicsek, A. Articles by Hooper, D. C. Search for Related Content PubMed PubMed Citation Articles by Robicsek, A. Articles by Hooper, D. C.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, August 2006, p. 2872-2874, Vol. 50, No. 8
0066-4804/06/$08.00+0     doi:10.1128/AAC.01647-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

qnr Prevalence in Ceftazidime-Resistant Enterobacteriaceae Isolates from the United States

A. Robicsek,^1, J. Strahilevitz,¹ D. F. Sahm,² G. A. Jacoby,³ and D. C. Hooper^1*

Massachusetts General Hospital, Boston, Massachusetts,¹ Focus BioInova, Herndon, Virginia,² Lahey Clinic, Burlington, Massachusetts³

Received 29 December 2005/ Returned for modification 15 February 2006/ Accepted 27 April 2006

We screened 313 ceftazidime-resistant Enterobacteriaceae isolates obtained in the United States from 1999 to 2004 for all three known qnr genes. A qnr gene was present in 20% of Klebsiella pneumoniae isolates, 31% of Enterobacter sp. isolates, and 4% of Escherichia coli isolates. qnrA and qnrB occurred with equivalent frequencies and, except for qnrB in enterobacters, were stable over time. qnrS was absent.

Present address: Evanston Northwestern Healthcare, Evanston, Illinois.

This article has been cited by other articles:

• Szabo, D., Kocsis, B., Rokusz, L., Szentandrassy, J., Katona, K., Kristof, K., Nagy, K. (2008). First detection of plasmid-mediated, quinolone resistance determinants qnrA, qnrB, qnrS and aac(6')-Ib-cr in extended-spectrum {beta}-lactamase (ESBL)-producing Enterobacteriaceae in Budapest, Hungary. J Antimicrob Chemother 62: 630-632 [Full Text]  
• Liu, J.-H., Deng, Y.-T., Zeng, Z.-L., Gao, J.-H., Chen, L., Arakawa, Y., Chen, Z.-L. (2008). Coprevalence of Plasmid-Mediated Quinolone Resistance Determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA Methylase RmtB-Producing Escherichia coli Isolates from Pigs. Antimicrob. Agents Chemother. 52: 2992-2993 [Full Text]  
• Chmelnitsky, I., Navon-Venezia, S., Strahilevitz, J., Carmeli, Y. (2008). Plasmid-Mediated qnrB2 and Carbapenemase Gene blaKPC-2 Carried on the Same Plasmid in Carbapenem-Resistant Ciprofloxacin-Susceptible Enterobacter cloacae Isolates. Antimicrob. Agents Chemother. 52: 2962-2965 [Abstract] [Full Text]  
• Lascols, C., Podglajen, I., Verdet, C., Gautier, V., Gutmann, L., Soussy, C.-J., Collatz, E., Cambau, E. (2008). A Plasmid-Borne Shewanella algae Gene, qnrA3, and Its Possible Transfer In Vivo between Kluyvera ascorbata and Klebsiella pneumoniae. J. Bacteriol. 190: 5217-5223 [Abstract] [Full Text]  
• Liassine, N., Zulueta-Rodriguez, P., Corbel, C., Lascols, C., Soussy, C.-J., Cambau, E. (2008). First detection of plasmid-mediated quinolone resistance in the community setting and in hospitalized patients in Switzerland. J Antimicrob Chemother 0: dkn295v1-2 [Full Text]  
• Endimiani, A., Carias, L. L., Hujer, A. M., Bethel, C. R., Hujer, K. M., Perez, F., Hutton, R. A., Fox, W. R., Hall, G. S., Jacobs, M. R., Paterson, D. L., Rice, L. B., Jenkins, S. G., Tenover, F. C., Bonomo, R. A. (2008). Presence of Plasmid-Mediated Quinolone Resistance in Klebsiella pneumoniae Isolates Possessing blaKPC in the United States. Antimicrob. Agents Chemother. 52: 2680-2682 [Abstract] [Full Text]  
• Jacoby, G., Cattoir, V., Hooper, D., Martinez-Martinez, L., Nordmann, P., Pascual, A., Poirel, L., Wang, M. (2008). qnr Gene Nomenclature. Antimicrob. Agents Chemother. 52: 2297-2299 [Full Text]  
• Pazhani, G. P., Niyogi, S. K., Singh, A. K., Sen, B., Taneja, N., Kundu, M., Yamasaki, S., Ramamurthy, T. (2008). Molecular characterization of multidrug-resistant Shigella species isolated from epidemic and endemic cases of shigellosis in India. J Med Microbiol 57: 856-863 [Abstract] [Full Text]  
• Wu, J.-J., Ko, W.-C., Wu, H.-M., Yan, J.-J. (2008). Prevalence of Qnr determinants among bloodstream isolates of Escherichia coli and Klebsiella pneumoniae in a Taiwanese Hospital, 1999-2005. J Antimicrob Chemother 61: 1234-1239 [Abstract] [Full Text]  
• Jurado, S., Orden, J. A., Horcajo, P., De La Fuente, R., Ruiz-Santa-Quiteria, J. A., Martinez-Pulgarin, S., Dominguez-Bernal, G. (2008). Characterization of fluoroquinolone resistance in Escherichia coli strains from ruminants. jvdi 20: 342-345 [Abstract] [Full Text]  
• Pitout, J. D. D., Wei, Y., Church, D. L., Gregson, D. B. (2008). Surveillance for plasmid-mediated quinolone resistance determinants in Enterobacteriaceae within the Calgary Health Region, Canada: the emergence of aac(6')-Ib-cr. J Antimicrob Chemother 61: 999-1002 [Abstract] [Full Text]  
• Jiang, Y., Zhou, Z., Qian, Y., Wei, Z., Yu, Y., Hu, S., Li, L. (2008). Plasmid-mediated quinolone resistance determinants qnr and aac(6')-Ib-cr in extended-spectrum {beta}-lactamase-producing Escherichia coli and Klebsiella pneumoniae in China. J Antimicrob Chemother 61: 1003-1006 [Abstract] [Full Text]  
• Cesaro, A., Bettoni, R. R. D., Lascols, C., Merens, A., Soussy, C. J., Cambau, E. (2008). Low selection of topoisomerase mutants from strains of Escherichia coli harbouring plasmid-borne qnr genes. J Antimicrob Chemother 61: 1007-1015 [Abstract] [Full Text]  
• Yamane, K., Wachino, J.-i., Suzuki, S., Arakawa, Y. (2008). Plasmid-Mediated qepA Gene among Escherichia coli Clinical Isolates from Japan. Antimicrob. Agents Chemother. 52: 1564-1566 [Abstract] [Full Text]  
• Kang, H. Y., Kim, K. Y., Kim, J., Lee, J. C., Lee, Y. C., Cho, D. T., Seol, S. Y. (2008). Distribution of Conjugative-Plasmid-Mediated 16S rRNA Methylase Genes among Amikacin-Resistant Enterobacteriaceae Isolates Collected in 1995 to 1998 and 2001 to 2006 at a University Hospital in South Korea and Identification of Conjugative Plasmids Mediating Dissemination of 16S rRNA Methylase. J. Clin. Microbiol. 46: 700-706 [Abstract] [Full Text]  
• Xu, X., Wu, S., Ye, X., Liu, Y., Shi, W., Zhang, Y., Wang, M. (2007). Prevalence and Expression of the Plasmid-Mediated Quinolone Resistance Determinant qnrA1. Antimicrob. Agents Chemother. 51: 4105-4110 [Abstract] [Full Text]  
• Le, T. A. H., Fabre, L., Roumagnac, P., Grimont, P. A. D., Scavizzi, M. R., Weill, F.-X. (2007). Clonal Expansion and Microevolution of Quinolone-Resistant Salmonella enterica Serotype Typhi in Vietnam from 1996 to 2004. J. Clin. Microbiol. 45: 3485-3492 [Abstract] [Full Text]  
• Ahmed, A. M., Motoi, Y., Sato, M., Maruyama, A., Watanabe, H., Fukumoto, Y., Shimamoto, T. (2007). Zoo Animals as Reservoirs of Gram-Negative Bacteria Harboring Integrons and Antimicrobial Resistance Genes. Appl. Environ. Microbiol. 73: 6686-6690 [Abstract] [Full Text]  
• Park, Y.-J., Yu, J. K., Lee, S., Oh, E.-J., Woo, G.-J. (2007). Prevalence and diversity of qnr alleles in AmpC-producing Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii and Serratia marcescens: a multicentre study from Korea. J Antimicrob Chemother 60: 868-871 [Abstract] [Full Text]  
• Arpin, C., Coulange, L., Dubois, V., Andre, C., Fischer, I., Fourmaux, S., Grobost, F., Jullin, J., Dutilh, B., Couture, J.-F., Noury, P., Lagrange, I., Ducastaing, A., Doermann, H.-P., Quentin, C. (2007). Extended-Spectrum-{beta}-Lactamase-Producing Enterobacteriaceae Strains in Various Types of Private Health Care Centers. Antimicrob. Agents Chemother. 51: 3440-3444 [Abstract] [Full Text]  
• Cattoir, V., Poirel, L., Rotimi, V., Soussy, C.-J., Nordmann, P. (2007). Multiplex PCR for detection of plasmid-mediated quinolone resistance qnr genes in ESBL-producing enterobacterial isolates. J Antimicrob Chemother 60: 394-397 [Abstract] [Full Text]  
• Strahilevitz, J., Engelstein, D., Adler, A., Temper, V., Moses, A. E., Block, C., Robicsek, A. (2007). Changes in qnr Prevalence and Fluoroquinolone Resistance in Clinical Isolates of Klebsiella pneumoniae and Enterobacter spp. Collected from 1990 to 2005. Antimicrob. Agents Chemother. 51: 3001-3003 [Abstract] [Full Text]  
• Pallecchi, L., Bartoloni, A., Fiorelli, C., Mantella, A., Di Maggio, T., Gamboa, H., Gotuzzo, E., Kronvall, G., Paradisi, F., Rossolini, G. M. (2007). Rapid Dissemination and Diversity of CTX-M Extended-Spectrum {beta}-Lactamase Genes in Commensal Escherichia coli Isolates from Healthy Children from Low-Resource Settings in Latin America. Antimicrob. Agents Chemother. 51: 2720-2725 [Abstract] [Full Text]  
• Cattoir, V., Poirel, L., Nordmann, P. (2007). Plasmid-Mediated Quinolone Resistance Determinant QnrB4 Identified in France in an Enterobacter cloacae Clinical Isolate Coexpressing a QnrS1 Determinant. Antimicrob. Agents Chemother. 51: 2652-2653 [Full Text]  
• Hopkins, K. L., Wootton, L., Day, M. R., Threlfall, E. J. (2007). Plasmid-mediated quinolone resistance determinant qnrS1 found in Salmonella enterica strains isolated in the UK. J Antimicrob Chemother 59: 1071-1075 [Abstract] [Full Text]  
• Wu, J.-J., Ko, W.-C., Tsai, S.-H., Yan, J.-J. (2007). Prevalence of Plasmid-Mediated Quinolone Resistance Determinants QnrA, QnrB, and QnrS among Clinical Isolates of Enterobacter cloacae in a Taiwanese Hospital. Antimicrob. Agents Chemother. 51: 1223-1227 [Abstract] [Full Text]  
• Pai, H., Seo, M.-R., Choi, T. Y. (2007). Association of QnrB Determinants and Production of Extended-Spectrum {beta}-Lactamases or Plasmid-Mediated AmpC {beta}-Lactamases in Clinical Isolates of Klebsiella pneumoniae. Antimicrob. Agents Chemother. 51: 366-368 [Abstract] [Full Text]  
• Poirel, L., Leviandier, C., Nordmann, P. (2006). Prevalence and Genetic Analysis of Plasmid-Mediated Quinolone Resistance Determinants QnrA and QnrS in Enterobacteriaceae Isolates from a French University Hospital. Antimicrob. Agents Chemother. 50: 3992-3997 [Abstract] [Full Text]  
• Park, C. H., Robicsek, A., Jacoby, G. A., Sahm, D., Hooper, D. C. (2006). Prevalence in the United States of aac(6')-Ib-cr Encoding a Ciprofloxacin-Modifying Enzyme. Antimicrob. Agents Chemother. 50: 3953-3955 [Abstract] [Full Text]