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Antimicrobial Agents and Chemotherapy, August 2006, p. 2883-2885, Vol. 50, No. 8
0066-4804/06/$08.00+0     doi:10.1128/AAC.00177-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

In Vitro Interactions between Piperaquine, Dihydroartemisinin, and Other Conventional and Novel Antimalarial Drugs

Timothy M. E. Davis,1* Juliana Hamzah,1 Kenneth F. Ilett,1 Harin A. Karunajeewa,1 John C. Reeder,2 Kevin T. Batty,3 Sara Hackett,1 and P. Hugh R. Barrett1

School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia,1 Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea,2 School of Pharmacy, Curtin University, Bentley, Western Australia, Australia3

Received 9 February 2006/ Returned for modification 16 February 2006/ Accepted 9 May 2006

In an in vitro assessment of antimalarial combinations, dihydroartemisinin (DHA) showed no interaction or was mildly antagonistic when combined with piperaquine, pyronaridine, or naphthoquine. Interactions between 4-aminoquinolines and related drugs were also indifferent/antagonistic. The clinical significance of mildly antagonistic DHA combinations is uncertain but may become important if parasite drug sensitivity declines.

* Corresponding author. Mailing address: University of Western Australia, School of Medicine and Pharmacology, Fremantle Hospital, P.O. Box 480, Fremantle, Western Australia 6959. Phone: (618) 9431 3229. Fax: (618) 9431 2977. E-mail: tdavis{at}cyllene.uwa.edu.au.

Antimicrobial Agents and Chemotherapy, August 2006, p. 2883-2885, Vol. 50, No. 8
0066-4804/06/$08.00+0     doi:10.1128/AAC.00177-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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