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Antimicrobial Agents and Chemotherapy, August 2006, p. 2886-2888, Vol. 50, No. 8
0066-4804/06/$08.00+0     doi:10.1128/AAC.01060-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Cysteine Proteinase Inhibitors in Murine Cysticercosis

Salman Baig,1,3 Raymond T. Damian,1 Jorge Morales-Montor,1,2 Rupal Thazhath,1 Amr Ghaleb,1 Meredith Welch,1 Jamil Talhouk,4 and A. Clinton White Jr.3*

Department of Cellular Biology, University of Georgia, Biological Sciences Building, Athens, Georgia 30603,1 Departamento de Inmunología, Instituto de Investigaciones Biomédicas, UNAM AP 70228, Mexico City DF 04510, México,2 Infectious Diseases Section, Department of Medicine, Baylor College of Medicine, 1 Baylor Plaza, 535EA, Houston, Texas 77030,3 Enzyme Systems Products, Livermore, California4

Received 15 August 2005/ Returned for modification 2 September 2005/ Accepted 8 December 2005

We explored the prophylactic efficacies of two novel protease inhibitors in murine cysticercosis. Our results demonstrated a 95% and 80% reduction in parasite burden for mice injected with Z-LLL-FMK and Z-LLY-FMK, respectively. Further studies are merited on the role of cysteine proteinase inhibitors in treatment of cysticercosis.

* Corresponding author. Mailing address: Infectious Disease Section, Department of Medicine, One Baylor Plaza 535EA, Houston, TX 77030. Phone: (713) 798-5246. Fax: (713) 790-0681. E-mail: arthurw{at}bcm.tmc.edu.

Antimicrobial Agents and Chemotherapy, August 2006, p. 2886-2888, Vol. 50, No. 8
0066-4804/06/$08.00+0     doi:10.1128/AAC.01060-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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