This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Katiyar, S. Articles by Edlind, T. Search for Related Content PubMed PubMed Citation Articles by Katiyar, S. Articles by Edlind, T.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, August 2006, p. 2892-2894, Vol. 50, No. 8
0066-4804/06/$08.00+0     doi:10.1128/AAC.00349-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Candida albicans and Candida glabrata Clinical Isolates Exhibiting Reduced Echinocandin Susceptibility

Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129,¹ Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242²

Received 22 March 2006/ Returned for modification 10 May 2006/ Accepted 2 June 2006

A recognized hotspot for mutations conferring reduced echinocandin susceptibility (RES) is residue S645 of Candida albicans Gsc1(Fks1). We report that the mutation F641Y is associated with RES in a C. albicans isolate. The analogous Fks2 residue is mutated F to V in a Candida glabrata RES isolate; the introduction of this mutation into susceptible C. glabrata confirmed its role in RES. Y641-equivalent Fks residues were identified in intrinsically RES Fusarium species and Candida guilliermondii.

This article has been cited by other articles:

• Thompson, G. R. III, Wiederhold, N. P., Vallor, A. C., Villareal, N. C., Lewis, J. S. II, Patterson, T. F. (2008). Development of Caspofungin Resistance following Prolonged Therapy for Invasive Candidiasis Secondary to Candida glabrata Infection. Antimicrob. Agents Chemother. 52: 3783-3785 [Abstract] [Full Text]  
• Desnos-Ollivier, M., Bretagne, S., Raoux, D., Hoinard, D., Dromer, F., Dannaoui, E. (2008). Mutations in the fks1 Gene in Candida albicans, C. tropicalis, and C. krusei Correlate with Elevated Caspofungin MICs Uncovered in AM3 Medium Using the Method of the European Committee on Antibiotic Susceptibility Testing. Antimicrob. Agents Chemother. 52: 3092-3098 [Abstract] [Full Text]  
• Garcia-Effron, G., Katiyar, S. K., Park, S., Edlind, T. D., Perlin, D. S. (2008). A Naturally Occurring Proline-to-Alanine Amino Acid Change in Fks1p in Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis Accounts for Reduced Echinocandin Susceptibility. Antimicrob. Agents Chemother. 52: 2305-2312 [Abstract] [Full Text]  
• Desnos-Ollivier, M., Dromer, F., Dannaoui, E. (2008). Detection of Caspofungin Resistance in Candida spp. by Etest. J. Clin. Microbiol. 46: 2389-2392 [Abstract] [Full Text]  
• Cleary, J. D., Garcia-Effron, G., Chapman, S. W., Perlin, D. S. (2008). Reduced Candida glabrata Susceptibility Secondary to an FKS1 Mutation Developed during Candidemia Treatment. Antimicrob. Agents Chemother. 52: 2263-2265 [Abstract] [Full Text]  
• Baixench, M.-T., Aoun, N., Desnos-Ollivier, M., Garcia-Hermoso, D., Bretagne, S., Ramires, S., Piketty, C., Dannaoui, E. (2007). Acquired resistance to echinocandins in Candida albicans: case report and review. J Antimicrob Chemother 59: 1076-1083 [Abstract] [Full Text]  
• Kahn, J. N., Garcia-Effron, G., Hsu, M.-J., Park, S., Marr, K. A., Perlin, D. S. (2007). Acquired Echinocandin Resistance in a Candida krusei Isolate Due to Modification of Glucan Synthase. Antimicrob. Agents Chemother. 51: 1876-1878 [Abstract] [Full Text]  
• Pfaller, M. A., Diekema, D. J. (2007). Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem. Clin. Microbiol. Rev. 20: 133-163 [Abstract] [Full Text]