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Antimicrobial Agents and Chemotherapy, September 2006, p. 2971-2975, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00015-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

MarA-Like Regulator of Multidrug Resistance in Yersinia pestis

Rupa A. Udani^1, and Stuart B. Levy^1,2*

Center of Adaptation Genetics and Drug Resistance and Department of Molecular Biology and Microbiology,¹ Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111²

Received 5 January 2006/ Returned for modification 2 March 2006/ Accepted 27 June 2006

MarA47_Yp from Yersinia pestis, showing 47% identity to Escherichia coli MarA in its N terminus, caused resistance to antibiotics and to organic solvents when expressed in both E. coli and Y. pestis. Resistance was linked to increased expression of the AcrAB multidrug efflux pump. In four of five spontaneous multidrug-resistant mutants of Y. pestis independently selected by growth on tetracycline, the marA47_Yp gene was overexpressed. The findings suggest that marA47_Yp is a marA ortholog in Y. pestis.

Present address: Prodesse, Inc., W229 N1870 Westwood Dr., Waukesha, WI 53186.