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Antimicrobial Agents and Chemotherapy, September 2006, p. 3070-3074, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.01578-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Inhibition of Human Immunodeficiency Virus Type 1 Entry by a Binding Domain of Porphyromonas gingivalis Gingipain

Hua Xie,1* Natalya I. Belogortseva,1 Jie Wu,1 Wei-Hong Lai,2 and Chin-ho Chen2

School of Dentistry, Meharry Medical College, Nashville, Tennessee,1 Duke University, Durham, North Carolina2

Received 12 December 2005/ Returned for modification 27 February 2006/ Accepted 7 June 2006

Human immunodeficiency virus (HIV) transmission through saliva is extremely low. Several oral components, including secretory immunoglobulin A and secretory leukocyte protease inhibitor, are known as potential inhibitory agents of HIV oral transmission. Here we examined anti-HIV activity of oral bacterial components. We showed that recombinant protein HGP44 derived from Porphyromonas gingivalis, one of the primary infectious agents of periodontitis, was capable of inhibiting HIV type 1 (HIV-1) replication. HGP44 bound specifically to HIV-1 gp120 and blocked HIV-1 envelope-mediated membrane fusion. These findings suggest that HGP44 of P. gingivalis can inhibit HIV-1 infection by blocking HIV-1 entry.

* Corresponding author. Mailing address: School of Dentistry, Meharry Medical College, Nashville, TN 37208. Phone: (615) 327 5981. Fax: (615) 327 5959. E-mail: hxie{at}mmc.edu.

Antimicrobial Agents and Chemotherapy, September 2006, p. 3070-3074, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.01578-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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