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Antimicrobial Agents and Chemotherapy, September 2006, p. 3098-3101, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00438-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Plasmid-Mediated Imipenem-Hydrolyzing Enzyme KPC-2 among Multiple Carbapenem-Resistant Escherichia coli Clones in Israel

Shiri Navon-Venezia,* Inna Chmelnitsky, Azita Leavitt, Mitchell J. Schwaber, David Schwartz, and Yehuda Carmeli

Division of Epidemiology and the Laboratory for Molecular Epidemiology and Antibiotic Research, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Received 6 April 2006/ Returned for modification 14 May 2006/ Accepted 12 June 2006

Carbapenem resistance in Escherichia coli is rare. We report four genetically unrelated carbapenem-resistant E. coli isolates cultured from four patients hospitalized in Tel Aviv Medical Center. PCR, sequencing, and Southern blot analysis identified KPC-2 as the imipenem-hydrolyzing enzyme in all four strains, carried on different plasmids with a possible common origin. This is the first discovery of KPC-2 in E. coli and the first report of this enzyme originating outside the United States.

* Corresponding author. Mailing address: Division of Epidemiology, Tel Aviv Sourasky Medical Center, 6 Weizmann St., Tel Aviv 64239, Israel. Phone: 972 3 692 5644. Fax: 972 3 697 4966. E-mail: shiri_nv{at}tasmc.health.gov.il.

Antimicrobial Agents and Chemotherapy, September 2006, p. 3098-3101, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00438-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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