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Antimicrobial Agents and Chemotherapy, September 2006, p. 3146-3149, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00205-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Prior Antibacterial Peptide-Mediated Inhibition of Protein Folding in Bacteria Mutes Resistance Enzymes

Laszlo Otvos Jr.,1,2* Vanessa de Olivier Inacio,3 John D. Wade,4 and Predrag Cudic3

Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, Pennsylvania 19122,1 The Wistar Institute, Philadelphia, Pennsylvania 19104,2 Florida Atlantic University, Boca Raton, Florida 33431,3 Howard Florey Institute, Parkville, 3052 Victoria, Australia4

Received 16 February 2006/ Returned for modification 12 April 2006/ Accepted 9 June 2006

The antimicrobial activity of amoxicillin against TEM-1-expressing strains could be fully recovered when bacteria were preincubated with sublethal doses of an antibacterial peptide derivative. Assays with the simultaneous administration of antibiotics or synergy assays with kanamycin or ciprofloxacin, where resistance development does not involve properly folded proteins, failed to yield similar results.

* Corresponding author. Mailing address: Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, BioLife Sciences Building, Rm. 419, 1900 North 12th Street, Philadelphia, PA 19122. Phone: (215) 204-4020. Fax: (215) 204-4021. E-mail: otvos{at}temple.edu.

Antimicrobial Agents and Chemotherapy, September 2006, p. 3146-3149, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00205-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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