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Antimicrobial Agents and Chemotherapy, September 2006, p. 3166-3169, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00322-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

In Vitro Activity of Tigecycline against Multiple-Drug-Resistant, Including Pan-Resistant, Gram-Negative and Gram-Positive Clinical Isolates from Greek Hospitals

Maria Souli,1 Flora V. Kontopidou,1 Evangelos Koratzanis,1 Anastasia Antoniadou,1 Efthimia Giannitsioti,1 Pinelopi Evangelopoulou,1 Sofia Kannavaki,2 and Helen Giamarellou1*

Fourth Department of Internal Medicine, Athens University School of Medicine, University General Hospital "Attikon," 1 Rimini Street, 124 62 Chaidari, Greece,1 Department of Clinical Microbiology, "Sotiria" Hospital, Mesogeion Avenue, Athens, Greece2

Received 16 March 2006/ Returned for modification 12 April 2006/ Accepted 14 June 2006

The in vitro activities of tigecycline and selected antimicrobials were evaluated against a variety of multiple-drug-resistant clinical isolates, including extended-spectrum ß-lactamase- and/or metallo-ß-lactamase-producing gram-negative strains, colistin-resistant strains, vancomycin- and/or linezolid-resistant enterococci, and methicillin-resistant Staphylococcus aureus (MRSA). Tigecycline showed excellent activity against a collection of difficult-to-treat pathogens currently encountered in the hospital setting.

* Corresponding author. Mailing address: 4th Department of Internal Medicine, University General Hospital "Attikon," 1 Rimini Street, 124 62 Chaidari, Greece. Phone: 210 5831990. Fax: 210 5326446. E-mail: hgiama{at}ath.forthnet.gr.

Antimicrobial Agents and Chemotherapy, September 2006, p. 3166-3169, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00322-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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