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Antimicrobial Agents and Chemotherapy, September 2006, p. 3170-3172, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00571-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of DA-7157 and DA-7218 against Mycobacterium tuberculosis and Nocardia brasiliensis

Lucio Vera-Cabrera,1* Eva Gonzalez,1 Adrian Rendon,2 Jorge Ocampo-Candiani,1 Oliverio Welsh,1 Victor M. Velazquez-Moreno,1 Sung Hak Choi,3 and Carmen Molina-Torres1

Servicio de Dermatología, Hospital Universitario José E. González, Monterrey, N.L., México 64460,1 Servicio de Neumología, Hospital Universitario José E. González, Monterrey, N.L., México 64460,2 Research Laboratory, Dong-A Pharmaceutical Co., Ltd., Yongin, Korea3

Received 9 May 2006/ Returned for modification 7 June 2006/ Accepted 20 June 2006

The in vitro activities of DA-7157, a novel oxazolidinone, against clinical isolates of Nocardia brasiliensis and Mycobacterium tuberculosis were determined. Equal MIC50s and MIC90s (0.25 and 0.5 µg/ml, respectively) were found for susceptible and multidrug-resistant isolates of M. tuberculosis. The N. brasiliensis isolates showed an MIC90 of 1 µg/ml and an MIC50 of 1 µg/ml. The DA-7157 prodrug, DA-7218, exhibited similar MICs for M. tuberculosis but fivefold-higher MICs for N. brasiliensis.

* Corresponding author. Mailing address: Servicio de Dermatología, Hospital Universitario José E. González, Madero y Gonzalitos, Col. Mitras Centro, Monterrey, N.L., México. Phone: (5281) 8348-0383. Fax: (5281) 8348-4407. E-mail: luvera_99{at}yahoo.com.

Antimicrobial Agents and Chemotherapy, September 2006, p. 3170-3172, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00571-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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