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Antimicrobial Agents and Chemotherapy, September 2006, p. 3173-3174, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00427-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Intracellular Penetration and Activity of DX-619 in Human Polymorphonuclear Leukocytes

Isabel García,1* Sofía Ballesta,1 Concepción Murillo,2 Evelio J. Perea,1,2 and Álvaro Pascual1,2

Dept. of Microbiology, School of Medicine, University of Seville,1 Dept. of Microbiology, University Hospital Virgen Macarena, Seville, Spain2

Received 5 April 2006/ Returned for modification 7 May 2006/ Accepted 2 July 2006

The intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes have been evaluated. DX-619 reached intracellular concentrations 10 times higher than the extracellular concentrations reached. Uptake was rapid, reversible, nonsaturable, and affected by environmental temperature, some metabolic inhibitors, and a soluble membrane activator. DX-619 showed intracellular activity against Staphylococcus aureus.

* Corresponding author. Mailing address: Department of Microbiology, School of Medicine, Avda, Sánchez Pizjuán s/n, Seville-41009, Spain. Phone: 34 954552862. Fax: 34 954377413. E-mail: igarcial{at}us.es.

Antimicrobial Agents and Chemotherapy, September 2006, p. 3173-3174, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00427-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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