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Antimicrobial Agents and Chemotherapy, September 2006, p. 3175-3178, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00273-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

In Vivo Reversion to the Wild-Type ß-Lactam Resistance Phenotype Mediated by a Plasmid Carrying ampR and qnrA1 in Enterobacter cloacae

J. J. González-López, M. Sabaté, S. Lavilla, M. N. Larrosa, R. M. Bartolomé, and G. Prats*

Servicio de Microbiología, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain

Received 3 March 2006/ Returned for modification 1 May 2006/ Accepted 25 June 2006

Resistance to ß-lactams and quinolones in two isogenic Enterobacter cloacae isolates was studied. One was susceptible to cefoxitin and amoxicillin-clavulanate. The other one showed its natural ß-lactam resistance pattern. Both isolates had a nonfunctional AmpR regulator. However, within the second one, the presence of a plasmid carrying ampR and qnrA1 allowed reversion to the wild-type ß-lactam resistance phenotype and decreased susceptibility to fluoroquinolones.

* Corresponding author. Mailing address: Servicio de Microbiología, Hospital Vall d'Hebron, Pg. Vall d'Hebron 119-129, 08035 Barcelona, Spain. Phone: 34-93-2746817. Fax: 34-93-2746801. E-mail:gprats{at}vhebron.net.

Antimicrobial Agents and Chemotherapy, September 2006, p. 3175-3178, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00273-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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