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Antimicrobial Agents and Chemotherapy, September 2006, p. 3183-3185, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00388-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

A Novel Extended-Spectrum TEM-Type ß-Lactamase, TEM-138, from Salmonella enterica Serovar Infantis

Chedly Chouchani,1 Renaud Berlemont,2 Afef Masmoudi,3 Moreno Galleni,2 Jean-Marie Frere,2 Omrane Belhadj,1 and Kamel Ben-Mahrez1*

Laboratoire de Biochimie et de Biotechnologie, Faculté des Sciences de Tunis, 2092 El-Manar II, Tunisia,1 Laboratoire des Macromolécules Biologiques, Centre d'Ingénierie des Protéines, Université de Liège, 4000 Sart-Tilman, Belgique,2 Laboratoire de Bactériologie, CHU La Rabta, Tunisia3

Received 30 March 2006/ Returned for modification 6 May 2006/ Accepted 30 June 2006

A novel natural TEM ß-lactamase with extended-spectrum activity, TEM-138, was identified in a ceftazidime-resistant clinical isolate of Salmonella enterica serovar Infantis. Compared to TEM-1, TEM-138 contains the following mutations: E104K, N175I, and G238S. The blaTEM-138 gene was located on a 50-kb transferable plasmid. Expression studies with Escherichia coli revealed efficient ceftazidimase and cefotaximase activities for TEM-138.

* Corresponding author. Mailing address: Faculté des Sciences de Tunis, 2092 El-Manar II, Tunisia. Phone: 216 70 86 03 36. Fax: 216 70 86 03 36. E-mail: kamel.benmahrez{at}fst.rnu.tn.

Antimicrobial Agents and Chemotherapy, September 2006, p. 3183-3185, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00388-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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