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Antimicrobial Agents and Chemotherapy, September 2006, p. 3186-3188, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.01510-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Activity of Picolinic Acid in Combination with the Antiprotozoal Drug Quinacrine against Mycobacterium avium Complex

Toshiaki Shimizu and Haruaki Tomioka*

Department of Microbiology and Immunology, Shimane University School of Medicine, Izumo, Shimane 693-8501, Japan

Received 24 November 2005/ Returned for modification 31 January 2006/ Accepted 15 June 2006

We studied the in vitro and in vivo antimicrobial activities of picolinic acid (PA) in combination with the antiprotozoal drug quinacrine against intramacrophage Mycobacterium avium complex (MAC). Quinacrine significantly potentiated the anti-MAC activity of PA, suggesting the usefulness of this combination in the clinical control of MAC infection.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Shimane University School of Medicine, Izumo, Shimane 693-8501, Japan. Phone: 81(853) 20-2146. Fax: 81(853) 20-2145. E-mail: tomioka{at}med.shimane-u.ac.jp.

Antimicrobial Agents and Chemotherapy, September 2006, p. 3186-3188, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.01510-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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