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Antimicrobial Agents and Chemotherapy, September 2006, p. 3189-3191, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00526-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

In Vitro Activity of Daptomycin against Methicillin-Resistant Staphylococcus aureus, Including Heterogeneously Glycopeptide-Resistant Strains

Bram M. W. Diederen,2* Inge van Duijn,1 Piet Willemse,1 and Jan A. J. W. Kluytmans1

Laboratory for Microbiology and Infection Control, Amphia Hospital, Breda, The Netherlands,1 Laboratory of Medical Microbiology, St. Elisabeth Hospital, Tilburg, The Netherlands2

Received 28 April 2006/ Returned for modification 7 May 2006/ Accepted 9 June 2006

The purpose of the present study was to assess the in vitro activity of daptomycin against a well-defined collection of methicillin-resistant Staphylococcus aureus (MRSA) isolates (n = 98), including heterogeneously glycopeptide-resistant MRSA (hGISA) strains. Susceptibility testing was performed by using the Etest system. Daptomycin was potent against both glycopeptide-susceptible and hGISA strains.

* Corresponding author. Mailing address: Laboratory of Medical Microbiology, St. Elisabeth Hospital, P.O. Box 747, 5000 AS Tilburg, The Netherlands. Phone: 31 13 539 2655. Fax: 31 13 544 1264. E-mail: b.diederen{at}elisabeth.nl.

Antimicrobial Agents and Chemotherapy, September 2006, p. 3189-3191, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00526-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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