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Antimicrobial Agents and Chemotherapy, September 2006, p. 3192-3193, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00263-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Molecular Characterization of Resistance to Macrolides in Bartonella henselae

Unité des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de Médecine et de Pharmacie, Université de la Méditerranée, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France

Received 2 March 2006/ Returned for modification 11 April 2006/ Accepted 22 June 2006

We selected in vitro erythromycin-resistant strains of Bartonella henselae. The mutants obtained had point mutations in domain V of 23S rRNA and/or in ribosomal protein L4. One lymph node of a patient with cat-scratch disease had such a mutation in 23S rRNA, suggesting that natural resistant strains may infect humans.

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