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Antimicrobial Agents and Chemotherapy, September 2006, p. 3192-3193, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00263-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Molecular Characterization of Resistance to Macrolides in Bartonella henselae

Silpak Biswas, Didier Raoult, and Jean-Marc Rolain*

Unité des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de Médecine et de Pharmacie, Université de la Méditerranée, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France

Received 2 March 2006/ Returned for modification 11 April 2006/ Accepted 22 June 2006

We selected in vitro erythromycin-resistant strains of Bartonella henselae. The mutants obtained had point mutations in domain V of 23S rRNA and/or in ribosomal protein L4. One lymph node of a patient with cat-scratch disease had such a mutation in 23S rRNA, suggesting that natural resistant strains may infect humans.


* Corresponding author. Mailing address: Unité des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de Médecine et de Pharmacie, Université de la Méditerranée, 27 Blvd. Jean Moulin, 13385 Marseille Cedex 05, France. Phone: (33) 491 38 55 17. Fax: (33) 491 83 03 90. E-mail: jm.rolain{at}medecine.univ-mrs.fr.


Antimicrobial Agents and Chemotherapy, September 2006, p. 3192-3193, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00263-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.




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