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Antimicrobial Agents and Chemotherapy, September 2006, p. 3192-3193, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00263-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Molecular Characterization of Resistance to Macrolides in Bartonella henselae

Silpak Biswas, Didier Raoult, and Jean-Marc Rolain*

Unité des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de Médecine et de Pharmacie, Université de la Méditerranée, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France

Received 2 March 2006/ Returned for modification 11 April 2006/ Accepted 22 June 2006

We selected in vitro erythromycin-resistant strains of Bartonella henselae. The mutants obtained had point mutations in domain V of 23S rRNA and/or in ribosomal protein L4. One lymph node of a patient with cat-scratch disease had such a mutation in 23S rRNA, suggesting that natural resistant strains may infect humans.

* Corresponding author. Mailing address: Unité des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de Médecine et de Pharmacie, Université de la Méditerranée, 27 Blvd. Jean Moulin, 13385 Marseille Cedex 05, France. Phone: (33) 491 38 55 17. Fax: (33) 491 83 03 90. E-mail: jm.rolain{at}medecine.univ-mrs.fr.

Antimicrobial Agents and Chemotherapy, September 2006, p. 3192-3193, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00263-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • La Scola, B., Elkarkouri, K., Li, W., Wahab, T., Fournous, G., Rolain, J.-M., Biswas, S., Drancourt, M., Robert, C., Audic, S., Lofdahl, S., Raoult, D. (2008). Rapid comparative genomic analysis for clinical microbiology: The Francisella tularensis paradigm. Genome Res 18: 742-750 [Abstract] [Full Text]  
  • Biswas, S., Raoult, D., Rolain, J.-M. (2007). Molecular mechanisms of resistance to antibiotics in Bartonella bacilliformis. J Antimicrob Chemother 59: 1065-1070 [Abstract] [Full Text]  


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