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Antimicrobial Agents and Chemotherapy, September 2006, p. 3194-3196, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00246-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Identification of RNase 8 as a Novel Human Antimicrobial Protein

Bente Rudolph,1 Rainer Podschun,2 Hany Sahly,2 Sabine Schubert,2 Jens M. Schröder,1 and Jürgen Harder1*

Department of Dermatology,1 Institute for Infection Medicine, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany2

Received 27 February 2006/ Returned for modification 22 March 2006/ Accepted 7 July 2006

The antimicrobial activity of the human RNase A superfamily member RNase 8 was evaluated. Recombinant RNase 8 exhibited broad-spectrum microbicidal activity against potential pathogenic microorganisms (including multidrug-resistant strains) at micro- to nanomolar concentrations. Thus, RNase 8 was identified as a novel antimicrobial protein and may contribute to host defense.

* Corresponding author. Mailing address: Department of Dermatology, University Hospital Schleswig-Holstein, Campus Kiel, Schittenhelmstr. 7, 24105 Kiel, Germany. Phone: 49 431 5971598. Fax: 49 431 5975243. E-mail: jharder{at}dermatology.uni-kiel.de.

Antimicrobial Agents and Chemotherapy, September 2006, p. 3194-3196, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00246-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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