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Antimicrobial Agents and Chemotherapy, September 2006, p. 3197-3199, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00500-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Rapid Degradation of Oseltamivir Phosphate in Clinical Samples by Plasma Esterases

Niklas Lindegardh,1,2* Geraint R. Davies,1,3 Tran Tinh Hien,4 Jeremy Farrar,2,4 Pratap Singhasivanon,1 Nicholas P. J. Day,1,2 and Nicholas J. White1,2

Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand,1 Nuffield Department of Clinical Medicine, Centre for Tropical Medicine, University of Oxford, Oxford, United Kingdom,2 Wellcome Trust Centre for Clinical Tropical Medicine, University of Liverpool, Liverpool, United Kingdom,3 Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam4

Received 22 April 2006/ Returned for modification 26 May 2006/ Accepted 15 June 2006

The anti-influenza drug oseltamivir is an ester prodrug activated by hepatic carboxylesterases. Plasma esterases also convert up to 31.8% of the parent compound to the active metabolite after 4 h ex vivo, with wide interindividual variation. This source of error is removed by adding the esterase inhibitor dichlorvos to blood collection tubes.

* Corresponding author. Mailing address: Wellcome Trust-Mahidol University-Oxford Tropical Medicine Research Programme, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand. Phone: 66 23541395. Fax: 66 23549169. E-mail: niklas{at}tropmedres.ac.

Antimicrobial Agents and Chemotherapy, September 2006, p. 3197-3199, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00500-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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