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Antimicrobial Agents and Chemotherapy, September 2006, p. 3207-3211, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00059-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

High-Level Mupirocin Resistance within Methicillin-Resistant Staphylococcus aureus Pandemic Lineages

Eduardo Pérez-Roth,1 Celeste López-Aguilar,1 Julia Alcoba-Florez,2 and Sebastián Méndez-Álvarez1,3,4*

Laboratorio de Biología Molecular, Unidad de Investigación,1 Unidad de Microbiología, Hospital Universitario Nuestra Señora de Candelaria,2 Departamento de Biología Celular y Microbiología, Universidad de La Laguna, Santa Cruz de Tenerife,3 Investigador Asociado, Centro de Investigaciones Biológicas del Consejo Superior de Investigaciones Científicas, Madrid, Spain4

Received 13 January 2006/ Returned for modification 24 March 2006/ Accepted 2 July 2006

The methicillin-resistant Staphylococcus aureus (MRSA) population in the Hospital Universitario Nuestra Señora de Candelaria over a 5-year period (1998 to 2002) was marked by shifts in the circulation of pandemic clones. Here, we investigated the emergence of high-level mupirocin resistance (Hi-Mupr). In addition to clonal spread, transfer of ileS2-carrying plasmids played a significant role in the dissemination of Hi-Mupr among pandemic MRSA lineages.

* Corresponding author. Mailing address: Unidad de Investigación, Hospital Ntra. Sra. de Candelaria, Ctra. del Rosario s/n, 38010 Santa Cruz de Tenerife, Spain. Phone: 34-922-600080. Fax: 34-922-600562. E-mail: smenalv{at}gobiernodecanarias.org.

Antimicrobial Agents and Chemotherapy, September 2006, p. 3207-3211, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00059-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Babu, T., Rekasius, V., Parada, J. P., Schreckenberger, P., Challapalli, M. (2009). Mupirocin Resistance among Methicillin-Resistant Staphylococcus aureus-Colonized Patients at Admission to a Tertiary Care Medical Center. J. Clin. Microbiol. 47: 2279-2280 [Abstract] [Full Text]  
  • Gould, F. K., Brindle, R., Chadwick, P. R., Fraise, A. P., Hill, S., Nathwani, D., Ridgway, G. L., Spry, M. J., Warren, R. E., on behalf of the MRSA Working Party of the British, (2009). Guidelines (2008) for the prophylaxis and treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections in the United Kingdom. J Antimicrob Chemother 63: 849-861 [Abstract] [Full Text]  


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