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Antimicrobial Agents and Chemotherapy, September 2006, p. 3212-3215, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00550-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Mode of Transposition and Expression of 16S rRNA Methyltransferase Gene rmtC Accompanied by ISEcp1

Jun-ichi Wachino,1,2 Kunikazu Yamane,1 Kouji Kimura,1 Naohiro Shibata,1 Satowa Suzuki,1 Yasuyoshi Ike,2 and Yoshichika Arakawa1*

Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, Tokyo,1 Department of Bacteriology and Bacterial Infection Control, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan2

Received 3 May 2006/ Returned for modification 6 June 2006/ Accepted 18 June 2006

A newly identified 16S rRNA methyltransferase gene, rmtC, was accompanied by an ISEcp1 element at its 5' end. This ISEcp1 element, which contained a transposase gene, tnpA, provided a promoter activity for expression of the adjacent rmtC; and this structure enabled the rmtC gene to be transposed onto another plasmid in Escherichia coli.

* Corresponding author. Mailing address: Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashi-Murayama, Tokyo 208-0011, Japan. Phone: 81-42-561-0771, ext. 500. Fax: 81-42-561-7173. E-mail: yarakawa{at}nih.go.jp.

Antimicrobial Agents and Chemotherapy, September 2006, p. 3212-3215, Vol. 50, No. 9
0066-4804/06/$08.00+0     doi:10.1128/AAC.00550-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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