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Antimicrobial Agents and Chemotherapy, January 2007, p. 195-197, Vol. 51, No. 1
0066-4804/07/$08.00+0     doi:10.1128/AAC.00222-06

Increase in Nalidixic Acid Resistance among Non-Typhi Salmonella enterica Isolates in the United States from 1996 to 2003

Jennifer E. Stevenson,^1, Kathryn Gay,² Timothy J. Barrett,² Felicita Medalla,¹ Tom M. Chiller,¹ and Frederick J. Angulo^1*

Enteric Diseases Epidemiology Branch, Division of Foodborne, Bacterial and Mycotic Diseases, National Center for Zoonotic, Vectorborne and Enteric Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia,¹ Enteric Diseases Laboratory Preparedness Branch, Division of Foodborne, Bacterial and Mycotic Diseases, National Center for Zoonotic, Vectorborne and Enteric Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia²

Received 20 February 2006/ Returned for modification 5 April 2006/ Accepted 24 October 2006

Fluoroquinolones commonly are used to treat adult Salmonella infections. Fluoroquinolone treatment has failed for persons infected with nalidixic acid-resistant Salmonella. From 1996 to 2003, state public health laboratories forwarded 12,252 non-Typhi Salmonella enterica isolates to the Centers for Disease Control and Prevention for antimicrobial susceptibility testing; 203 (1.6%) of the isolates were nalidixic acid resistant, and 14 (7%) of those were ciprofloxacin resistant. Resistance to nalidixic acid significantly increased from 0.4% in 1996 to 2.3% in 2003. All ciprofloxacin-resistant isolates had at least one point mutation in the quinolone resistance determining region (QRDR) of gyrA and did not harbor qnr or have point mutations in the QRDR of gyrB, parC, or parE. Continued surveillance of antimicrobial resistance among non-Typhi S. enterica isolates is needed to mitigate the increasing prevalence of nalidixic acid resistance.

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* Corresponding author. Mailing address: Centers for Disease Control and Prevention, Mailstop D63, 1600 Clifton Rd., Atlanta, GA 30333. Phone: (404) 639-3315. Fax: (404) 639-3535. E-mail: fangulo{at}cdc.gov.

Published ahead of print on 6 November 2006.

Present address: WSU-Psychology, P.O. Box 644820, 233 Johnson Tower, Pullman, WA 99164-4820.

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Antimicrobial Agents and Chemotherapy, January 2007, p. 195-197, Vol. 51, No. 1
0066-4804/07/$08.00+0     doi:10.1128/AAC.00222-06

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