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Antimicrobial Agents and Chemotherapy, January 2007, p. 317-323, Vol. 51, No. 1
0066-4804/07/$08.00+0     doi:10.1128/AAC.01229-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

SGI1-K, a Variant of the SGI1 Genomic Island Carrying a Mercury Resistance Region, in Salmonella enterica Serovar Kentucky

Renee S. Levings,^1,2 Sally R. Partridge,^3, Steven P. Djordjevic,¹ and Ruth M. Hall^4*

New South Wales Department of Primary Industries, Elizabeth Macarthur Agricultural Institute, Microbiology and Immunology Section, Camden, New South Wales 2570, Australia,¹ Department of Biological Sciences, University of Wollongong, New South Wales 2522, Australia,² Department of Biological Sciences, Macquarie University, Sydney, New South Wales 2103, Australia,³ School of Molecular and Microbial Biosciences, The University of Sydney, New South Wales 2006, Australia⁴

Received 1 October 2006/ Accepted 30 October 2006

A multiple-antibiotic-resistant Salmonella enterica serovar Kentucky strain was found to contain SGI1-K, a variant form of the Salmonella genomic island 1 (SGI1) with an In4-type class 1 integron that contains only one cassette array, aacCA5-aadA7, and an adjacent mercury resistance module. Part of the 3'-conserved segment (3'-CS) of the integron, together with the inverted short segment from the right-hand end of the integron transposition module normally found between the 3'-CS and IS6100 in In4 family integrons, has been removed by an IS6100-mediated deletion. IRt, the right-hand inverted repeat found at the outer end of the integron, abuts a mercury resistance region instead of the usual SGI1 backbone segment. The mer module is a hybrid of those found in Tn501 and Tn21. This mer region and a further uncharacterized segment of at least 10 kb appear to have been incorporated between IRt and the SGI1 backbone. These findings demonstrate that the multidrug resistance region in SGI1 can incorporate new DNA segments in the same way as multiple antibiotic resistance regions in plasmids.

Published ahead of print on 6 November 2006.

Present address: Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, NSW 2145, Australia.

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