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Antimicrobial Agents and Chemotherapy, January 2007, p. 332-334, Vol. 51, No. 1
0066-4804/07/$08.00+0     doi:10.1128/AAC.00856-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Markers of Sulfadoxine-Pyrimethamine-Resistant Plasmodium falciparum in Placenta and Circulation of Pregnant Women{triangledown}

Frank P. Mockenhaupt,1* George Bedu-Addo,2 Claudia Junge,1 Lena Hommerich,1 Teunis A. Eggelte,3 and Ulrich Bienzle1

Institute of Tropical Medicine and International Health, Charité—University Medicine, Berlin, Germany,1 Department of Medicine, Komfo Anoyke Teaching Hospital, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana,2 Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Centre, Amsterdam, The Netherlands3

Received 13 July 2006/ Returned for modification 19 September 2006/ Accepted 23 October 2006

Placental sequestration of Plasmodium falciparum in pregnancy may impair the usefulness of molecular markers of sulfadoxine-pyrimethamine resistance. In 300 infected, delivering women, the concordance of PCR-restriction fragment length polymorphism-derived parasite resistance alleles in matched samples from placenta and circulation was 83 to 98%. Sulfadoxine-pyrimethamine resistance typing in peripheral blood is reasonably representative of P. falciparum infecting pregnant women.

* Corresponding author. Mailing address: Institute of Tropical Medicine and International Health, Spandauer Damm 130, 14050 Berlin, Germany. Phone: 49 30 30116 815. Fax: 49 30 30116 888. E-mail: frank.mockenhaupt{at}charite.de.

{triangledown} Published ahead of print on 6 November 2006.

Antimicrobial Agents and Chemotherapy, January 2007, p. 332-334, Vol. 51, No. 1
0066-4804/07/$08.00+0     doi:10.1128/AAC.00856-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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