AAC
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Other Versions of this Article:
AAC.00498-06v1
51/1/338    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yang, W.
Right arrow Articles by Huang, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yang, W.
Right arrow Articles by Huang, M.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, January 2007, p. 338-342, Vol. 51, No. 1
0066-4804/07/$08.00+0     doi:10.1128/AAC.00498-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Hepatitis C Virus (HCV) NS5B Nonnucleoside Inhibitors Specifically Block Single-Stranded Viral RNA Synthesis Catalyzed by HCV Replication Complexes In Vitro{triangledown}

Wengang Yang, Yongnian Sun, Avinash Phadke, Milind Deshpande, and Mingjun Huang*

Achillion Pharmaceuticals, New Haven, Connecticut 06511

Received 21 April 2006/ Returned for modification 1 June 2006/ Accepted 25 October 2006

Replication complexes of hepatitis C virus synthesized two major species of viral RNA in vitro, double stranded and single stranded. NS5B nonnucleoside inhibitors inhibited dose dependently the synthesis of single-stranded RNA but not double-stranded RNA. Moreover, replication complexes carrying a mutation resistant to a nonnucleoside inhibitor lost their susceptibilities to the inhibitor.

* Corresponding author. Mailing address: Achillion Pharmaceuticals, 300 George Street, New Haven, CT 06511. Phone: (203) 624-7000. Fax: (203) 624-7003. E-mail: mhuang{at}achillion.com.

{triangledown} Published ahead of print on 6 November 2006.

Antimicrobial Agents and Chemotherapy, January 2007, p. 338-342, Vol. 51, No. 1
0066-4804/07/$08.00+0     doi:10.1128/AAC.00498-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Clin. Vaccine Immunol. Clin. Microbiol. Rev.
J. Clin. Microbiol. ALL ASM JOURNALS

Copyright © 2007 by the American Society for Microbiology. All rights reserved.