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Antimicrobial Agents and Chemotherapy, January 2007, p. 338-342, Vol. 51, No. 1
0066-4804/07/$08.00+0     doi:10.1128/AAC.00498-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Hepatitis C Virus (HCV) NS5B Nonnucleoside Inhibitors Specifically Block Single-Stranded Viral RNA Synthesis Catalyzed by HCV Replication Complexes In Vitro{triangledown}

Wengang Yang, Yongnian Sun, Avinash Phadke, Milind Deshpande, and Mingjun Huang*

Achillion Pharmaceuticals, New Haven, Connecticut 06511

Received 21 April 2006/ Returned for modification 1 June 2006/ Accepted 25 October 2006

Replication complexes of hepatitis C virus synthesized two major species of viral RNA in vitro, double stranded and single stranded. NS5B nonnucleoside inhibitors inhibited dose dependently the synthesis of single-stranded RNA but not double-stranded RNA. Moreover, replication complexes carrying a mutation resistant to a nonnucleoside inhibitor lost their susceptibilities to the inhibitor.

* Corresponding author. Mailing address: Achillion Pharmaceuticals, 300 George Street, New Haven, CT 06511. Phone: (203) 624-7000. Fax: (203) 624-7003. E-mail: mhuang{at}achillion.com.

{triangledown} Published ahead of print on 6 November 2006.

Antimicrobial Agents and Chemotherapy, January 2007, p. 338-342, Vol. 51, No. 1
0066-4804/07/$08.00+0     doi:10.1128/AAC.00498-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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