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Antimicrobial Agents and Chemotherapy, January 2007, p. 343-345, Vol. 51, No. 1
0066-4804/07/$08.00+0     doi:10.1128/AAC.00742-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

In Vitro-Clinical Correlations for Amphotericin B Susceptibility in AIDS-Associated Cryptococcal Meningitis{triangledown} ,{dagger}

R. A. Larsen,1* M. Bauer,1 A. E. Brouwer,2,3,4 A. Sanchez,1 A. M. Thomas,5 A. Rajanuwong,6 W. Chierakul,2 S. J. Peacock,2,7 N. Day,2,7 N. J. White,2,7 M. G. Rinaldi,8 and T. S. Harrison3

Department of Medicine (Infectious Diseases), University of Southern California, Los Angeles, California,1 Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand,2 Department of Internal Medicine, St. George's Hospital Medical School, London, United Kingdom,3 Department of Internal Medicine, St. Radboud University Medical Center, Nijmegen, The Netherlands,4 Department of Statistics, University of Northern Colorado, Greeley, Colorado,5 Department of Medicine, Sappasithiprasong Hospital, Ubon Ratchathani, Thailand,6 Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom,7 Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas8

Received 16 June 2006/ Returned for modification 31 July 2006/ Accepted 15 October 2006

Reliable measures of antifungal drug susceptibility are needed. We tested the susceptibility of Cryptococcus neoformans from patients treated with amphotericin B. In vitro susceptibility employed a modified broth macrodilution method. We demonstrate a strong correlation between the quantitative measures of in vitro amphotericin B susceptibility and the quantitative response observed in patients.

* Corresponding author. Mailing address: Department of Medicine (Infectious Diseases), 2020 Zonal Ave., IRD Room 620, MC 9520, University of Southern California, Los Angeles, CA 90033. Phone: (323) 226-7556. Fax: (323) 226-2083. E-mail: rlarsen{at}usc.edu.

{triangledown} Published ahead of print on 23 October 2006.

{dagger} Supplemental material for this article may be found at http://aac.asm.org/.

Antimicrobial Agents and Chemotherapy, January 2007, p. 343-345, Vol. 51, No. 1
0066-4804/07/$08.00+0     doi:10.1128/AAC.00742-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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