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Antimicrobial Agents and Chemotherapy, January 2007, p. 359-360, Vol. 51, No. 1
0066-4804/07/$08.00+0     doi:10.1128/AAC.00795-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Aph(3')-IIc, an Aminoglycoside Resistance Determinant from Stenotrophomonas maltophilia{triangledown}

Aki Okazaki and Matthew B. Avison*

Bristol Centre for Antimicrobial Research and Evaluation, Department of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom

Received 1 July 2006/ Returned for modification 12 August 2006/ Accepted 23 October 2006

We report the characterization of an intrinsic, chromosomally carried aph(3')-IIc gene from Stenotrophomonas maltophilia clinical isolate K279a, encoding an aminoglycoside phosphotransferase enzyme that significantly increases MICs of kanamycin, neomycin, butirosin, and paromomycin when expressed in Escherichia coli. Disruption of aph(3')-IIc in K279a results in decreased MICs of these drugs.

* Corresponding author. Mailing address: Department of Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom. Phone: 44 (0)11792857528. Fax: 44 (0)1179287896. E-mail: matthewb.Avison{at}bris.ac.uk.

{triangledown} Published ahead of print on 6 November 2006.

Antimicrobial Agents and Chemotherapy, January 2007, p. 359-360, Vol. 51, No. 1
0066-4804/07/$08.00+0     doi:10.1128/AAC.00795-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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