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Antimicrobial Agents and Chemotherapy, January 2007, p. 366-368, Vol. 51, No. 1
0066-4804/07/$08.00+0     doi:10.1128/AAC.00841-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Association of QnrB Determinants and Production of Extended-Spectrum ß-Lactamases or Plasmid-Mediated AmpC ß-Lactamases in Clinical Isolates of Klebsiella pneumoniae{triangledown}

Hyunjoo Pai,* Mi-Ran Seo, and Tae Yeal Choi

Division of Infectious Diseases and Clinical Microbiology, College of Medicine, Hanyang University, Seoul, Korea

Received 11 July 2006/ Returned for modification 12 September 2006/ Accepted 20 October 2006

Clinical isolates of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum ß-lactamases or plasmid-mediated AmpC ß-lactamases were screened for qnrA and qnrB genes. QnrB was present in 54 of 54 DHA-1-producing K. pneumoniae isolates and 10 of 45 SHV-12-producing ones, suggesting that the distribution of plasmids conferring resistance to extended-spectrum cephalosporins and quinolones in clinical isolates of K. pneumoniae is widespread.

* Corresponding author. Mailing address: Division of Infectious Diseases, College of Medicine, Hanyang University, Seoul, 133-791, Korea. Phone: 82-2-2290-8356. Fax: 82-2-2298-9183. E-mail: paihj{at}hanyang.ac.kr.

{triangledown} Published ahead of print on 30 October 2006.

Antimicrobial Agents and Chemotherapy, January 2007, p. 366-368, Vol. 51, No. 1
0066-4804/07/$08.00+0     doi:10.1128/AAC.00841-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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