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Antimicrobial Agents and Chemotherapy, January 2007, p. 383-385, Vol. 51, No. 1
0066-4804/07/$08.00+0     doi:10.1128/AAC.00446-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Combination of Amphotericin B with Flucytosine Is Active In Vitro against Flucytosine-Resistant Isolates of Cryptococcus neoformans{triangledown}

Patrick Schwarz,1 Guilhem Janbon,1 Françoise Dromer,1 Olivier Lortholary,1,2 and Eric Dannaoui1,3*

Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, (CNRS FRE2849), Institut Pasteur, 75724 Paris Cedex 15, France,1 Université Paris Descartes, Faculté de Médecine, AP-HP, Hôpital Necker-Enfants-Malades, Service des Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker-Pasteur, 75743 Paris Cedex 15, France,2 Université Paris Descartes, Faculté de Médecine, AP-HP, Hôpital Européen Georges Pompidou, Unité de Parasitologie—Mycologie, 75015 Paris, France3

Received 10 April 2006/ Returned for modification 5 July 2006/ Accepted 6 October 2006

The combination of flucytosine and amphotericin B was tested against 10 flucytosine-resistant isolates of Cryptococcus neoformans by checkerboard, killing curves, and Etest. Although differences were observed depending on the technique used, antagonism was never observed. The synergistic interaction was related to the mechanism of flucytosine resistance of the isolates.

* Corresponding author. Mailing address: Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, CNRS FRE2849, Institut Pasteur, 25 rue du Dr. Roux, 75724 Paris Cedex 15, France. Phone: 33 1 40 61 32 50. Fax: 33 1 45 68 84 20. E-mail: dannaoui{at}pasteur.fr.

{triangledown} Published ahead of print on 16 October 2006.

Antimicrobial Agents and Chemotherapy, January 2007, p. 383-385, Vol. 51, No. 1
0066-4804/07/$08.00+0     doi:10.1128/AAC.00446-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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