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Antimicrobial Agents and Chemotherapy, October 2007, p. 3672-3676, Vol. 51, No. 10
0066-4804/07/$08.00+0     doi:10.1128/AAC.00654-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Treatment of a Clinically Relevant Plant-Pathogenic Fungus with an Agricultural Azole Causes Cross-Resistance to Medical Azoles and Potentiates Caspofungin Efficacy{triangledown} ,{dagger}

Albrecht Serfling,1,{ddagger} Johannes Wohlrab,2 and Holger B. Deising1*

Faculty of Agriculture, Phytopathology and Plant Protection, Martin Luther University Halle-Wittenberg, D-06099 Halle (Saale), Germany,1 Faculty of Medicine, Department of Dermatology and Venereology, Martin Luther University Halle-Wittenberg, Ernst Kromayer Straße 5-6, D-06097 Halle (Saale), Germany2

Received 18 May 2007/ Returned for modification 16 June 2007/ Accepted 2 July 2007

Azoles are extensively applied in agriculture and medicine, and a relationship between the development of azole resistance in agriculture and the development of azole resistance in clinical practice may exist. The maize pathogen Colletotrichum graminicola, causing cutaneous mycosis and keratitis, has been used to investigate the acquisition of resistance to an agricultural azole and the resulting cross-resistance to various medical antifungal agents. Azole-adapted strains were less sensitive to all azoles tested but showed increased sensitivity to caspofungin, amphotericin B, and nystatin. Viability staining and infection assays with excised human skin confirmed these data.

* Corresponding author. Mailing address: Faculty of Natural Sciences III, Institute of Agricultural and Nutritional Sciences, Phytopathology and Plant Protection, Martin Luther University Halle-Wittenberg, D-06099 Halle (Saale), Germany. Phone: 49-345-5522660. Fax: 49-345-5527120. E-mail: holger.deising{at}landw.uni-halle.de

{triangledown} Published ahead of print on 9 July 2007.

{dagger} Supplemental material for this article may be found at http://aac.asm.org/.

{ddagger} Present address: Sächsische Landesanstalt für Landwirtschaft, Fachbereich Landwirtschaftliches Untersuchungswesen, Gustav Kühn Straße 8, D-04159 Leipzig, Germany.

Antimicrobial Agents and Chemotherapy, October 2007, p. 3672-3676, Vol. 51, No. 10
0066-4804/07/$08.00+0     doi:10.1128/AAC.00654-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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