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Antimicrobial Agents and Chemotherapy, October 2007, p. 3731-3733, Vol. 51, No. 10
0066-4804/07/$08.00+0     doi:10.1128/AAC.00101-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Impact of Empirical-Therapy Selection on Outcomes of Intravenous Drug Users with Infective Endocarditis Caused by Methicillin-Susceptible Staphylococcus aureus{triangledown}

Thomas P. Lodise Jr.,1* Peggy S. McKinnon,2 Donald P. Levine,3,4 and Michael J. Rybak3,4,5

Albany College of Pharmacy, Albany, New York,1 Barnes-Jewish Hospital, St. Louis, Missouri,2 School of Medicine, Wayne State University, Detroit, Michigan,3 Detroit Receiving Hospital and University Health Center, Detroit, Michigan,4 Anti-Infective Laboratory, College of Pharmacy & Health Sciences, Wayne State University, Detroit, Michigan5

Received 24 January 2007/ Returned for modification 15 March 2007/ Accepted 23 July 2007

This study compares beta-lactam and vancomycin among intravenous drug users with infective endocarditis caused by methicillin-susceptible Staphylococcus aureus. Patients who received vancomycin had higher infection-related mortality, even if they were switched to beta-lactam once culture results became available; this relationship persisted after logistic regression analysis controlling for clinical characteristics.

* Corresponding author. Mailing address: Albany College of Pharmacy, 106 New Scotland Avenue, Albany, NY 12208-3492. Phone: (518) 445-7292. Fax: (518) 445-7302. E-mail: lodiset{at}acp.edu

{triangledown} Published ahead of print on 30 July 2007.

Antimicrobial Agents and Chemotherapy, October 2007, p. 3731-3733, Vol. 51, No. 10
0066-4804/07/$08.00+0     doi:10.1128/AAC.00101-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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