AAC
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Other Versions of this Article:
AAC.00369-07v1
51/10/3734    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vetcher, L.
Right arrow Articles by Katz, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vetcher, L.
Right arrow Articles by Katz, L.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, October 2007, p. 3734-3736, Vol. 51, No. 10
0066-4804/07/$08.00+0     doi:10.1128/AAC.00369-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

The Antifungal Polyketide Ambruticin Targets the HOG Pathway{triangledown}

Leandro Vetcher,1 Hugo G. Menzella,1 Toshiaki Kudo,2 Takayuki Motoyama,2 and Leonard Katz1*

Kosan Biosciences, Inc., 3832 Bay Center Place, Hayward, California 94545,1 RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan2

Received 19 March 2007/ Returned for modification 13 June 2007/ Accepted 1 August 2007

The polyketide ambruticin is an attractive candidate for drug development as an antifungal agent, but its mechanism of action has not yet been elucidated. Here we present evidence that ambruticin exerts its effect by targeting HOG, the osmotic stress control pathway, through Hik1, a group III histidine kinase.

* Corresponding author. Mailing address: Leonard Katz Consulting, 6389 Longcroft Dr., Oakland, CA 94611. Phone and fax: (510) 336-7010. E-mail: katzl{at}pacbell.net

{triangledown} Published ahead of print on 13 August 2007.

Antimicrobial Agents and Chemotherapy, October 2007, p. 3734-3736, Vol. 51, No. 10
0066-4804/07/$08.00+0     doi:10.1128/AAC.00369-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Clin. Vaccine Immunol. Clin. Microbiol. Rev.
J. Clin. Microbiol. ALL ASM JOURNALS

Copyright © 2007 by the American Society for Microbiology. All rights reserved.