AAC
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Other Versions of this Article:
AAC.00492-07v1
51/10/3743    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Onyewu, C.
Right arrow Articles by Heitman, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Onyewu, C.
Right arrow Articles by Heitman, J.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, October 2007, p. 3743-3746, Vol. 51, No. 10
0066-4804/07/$08.00+0     doi:10.1128/AAC.00492-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Targeting the Calcineurin Pathway Enhances Ergosterol Biosynthesis Inhibitors against Trichophyton mentagrophytes In Vitro and in a Human Skin Infection Model{triangledown}

Chiatogu Onyewu,3 Emily Eads,2 Wiley A. Schell,2 John R. Perfect,2 Yehuda Ullmann,4 Gil Kaufman,5 Benjamin A. Horwitz,6 Israela Berdicevsky,5* and Joseph Heitman1,2,3*

Departments of Molecular Genetics and Microbiology,1 Medicine,2 Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710,3 Department of Plastic Surgery, Rambam Medical Center, Haifa, Israel,4 Faculty of Medicine, Molecular Microbiology,5 Biology, Technion—Israel Institute of Technology, Haifa, Israel6

Received 11 April 2007/ Returned for modification 24 May 2007/ Accepted 20 July 2007

Fluconazole-FK506 or fluconazole-cyclosporine drug combinations were tested in an ex vivo Trichophyton mentagrophytes human skin infection model. Conidia colonization was monitored by scanning electron microscopy over a 7-day treatment period. The fluconazole-FK506 combination demonstrated the most obvious advantage over single-drug therapy by clearing conidia and protecting skin from damage at low drug concentrations.

* Corresponding author. Mailing address for Joseph Heitman: Department of Molecular Genetics and Microbiology, 322 Carl Building, Box 3546, Research Drive, Duke University Medical Center, Durham, NC 27710. Phone: (919) 684-2824. Fax: (919) 684-5458. E-mail: heitm001{at}duke.edu. Mailing address for Israela Berdicevsky: Department of Molecular Microbiology, Faculty of Medicine, Technion—Israel Institute of Technology, Haifa 31096, Israel. Phone: (972) 48295293. Fax: (972) 48295225. E-mail: israelab{at}tx.technion.ac.il

{triangledown} Published ahead of print on 30 July 2007.

Antimicrobial Agents and Chemotherapy, October 2007, p. 3743-3746, Vol. 51, No. 10
0066-4804/07/$08.00+0     doi:10.1128/AAC.00492-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Clin. Vaccine Immunol. Clin. Microbiol. Rev.
J. Clin. Microbiol. ALL ASM JOURNALS

Copyright © 2007 by the American Society for Microbiology. All rights reserved.