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Antimicrobial Agents and Chemotherapy, October 2007, p. 3752-3755, Vol. 51, No. 10
0066-4804/07/$08.00+0     doi:10.1128/AAC.00572-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Targeting of the Brucella suis Virulence Factor Histidinol Dehydrogenase by Histidinol Analogues Results in Inhibition of Intramacrophagic Multiplication of the Pathogen{triangledown}

Pascale Joseph,1* Marie-Rose Abdo,2 Rose-Anne Boigegrain,1 Jean-Louis Montero,2 Jean-Yves Winum,2 and Stephan Köhler1

Centre d'Etudes d'Agents Pathogènes et Biotechnologies pour la Santé (CPBS) CNRS-UM1-UM2, UMR 5236, Université Montpellier II, 34095 Montpellier Cedex, France,1 Institut des Biomolécules Max Mousseron (IBMM), CNRS-UM1-UM2, UMR 5247, ENSCM, 34296 Montpellier, France2

Received 2 May 2007/ Returned for modification 2 July 2007/ Accepted 15 July 2007

Brucella suis histidinol dehydrogenase (HDH) can be efficiently targeted by substrate analogues. The growth of this pathogen in minimal medium was inhibited and the multiplication in human macrophages was totally abolished in the presence of the drugs. These effects have been shown to be correlated with the previously described inhibition of Brucella HDH activity.

* Corresponding author. Mailing address: Centre d'Etudes d'Agents Pathogènes et Biotechnologies pour la Santé (CPBS), CNRS-UM1-UM2, UMR 5236, Université Montpellier II, cc100, Place Eugène Bataillon, 34095 Montpellier Cedex, France. Phone: (33) 4 67 14 42 38. Fax: (33) 4 67 14 33 38. E-mail: pjoseph{at}univ-montp2.fr

{triangledown} Published ahead of print on 13 August 2007.

Antimicrobial Agents and Chemotherapy, October 2007, p. 3752-3755, Vol. 51, No. 10
0066-4804/07/$08.00+0     doi:10.1128/AAC.00572-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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