Antimicrobial Agents and Chemotherapy, October 2007, p. 3771-3774, Vol. 51, No. 10
0066-4804/07/$08.00+0 doi:10.1128/AAC.00099-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Pulmonary versus Systemic Delivery of Antibiotics: Comparison of Vancomycin Dispositions in the Isolated Rat Lung
María José de Jesús Valle,1
Francisco González López,1
Alfonso Domínguez-Gil Hurlé,1,2 and
Amparo Sánchez Navarro1*
Pharmacy Department, University of Salamanca, Licenciado Méndez Nieto, s/n 37007, Salamanca, Spain,1
University Hospital of Salamanca, Salamanca, Spain2
Received 24 January 2007/
Returned for modification 5 April 2007/
Accepted 23 July 2007
Vancomycin dispositions in the respiratory system were compared after systemic and inhalatory administration under two respiratory conditions using the isolated-lung model. Inhalatory delivery led to much higher drug levels in pulmonary tissue and fluids. The respiratory pattern affects vancomycin disposition in the pulmonary system regardless of the administration route.
* Corresponding author. Mailing address: Pharmacy Department, University of Salamanca, Licenciado Méndez Nieto, s/n 37007, Salamanca, Spain. Phone: 34 923 294536. Fax: 34 923 294515. E-mail: asn{at}usal.es
Published ahead of print on 6 August 2007.
Antimicrobial Agents and Chemotherapy, October 2007, p. 3771-3774, Vol. 51, No. 10
0066-4804/07/$08.00+0 doi:10.1128/AAC.00099-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Copyright © 2007 by the American Society for Microbiology. All rights reserved.