This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by de Jesús Valle, M. J.
Right arrow Articles by Navarro, A. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by de Jesús Valle, M. J.
Right arrow Articles by Navarro, A. S.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, October 2007, p. 3771-3774, Vol. 51, No. 10
0066-4804/07/$08.00+0     doi:10.1128/AAC.00099-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Pulmonary versus Systemic Delivery of Antibiotics: Comparison of Vancomycin Dispositions in the Isolated Rat Lung{triangledown}

María José de Jesús Valle,1 Francisco González López,1 Alfonso Domínguez-Gil Hurlé,1,2 and Amparo Sánchez Navarro1*

Pharmacy Department, University of Salamanca, Licenciado Méndez Nieto, s/n 37007, Salamanca, Spain,1 University Hospital of Salamanca, Salamanca, Spain2

Received 24 January 2007/ Returned for modification 5 April 2007/ Accepted 23 July 2007

Vancomycin dispositions in the respiratory system were compared after systemic and inhalatory administration under two respiratory conditions using the isolated-lung model. Inhalatory delivery led to much higher drug levels in pulmonary tissue and fluids. The respiratory pattern affects vancomycin disposition in the pulmonary system regardless of the administration route.

* Corresponding author. Mailing address: Pharmacy Department, University of Salamanca, Licenciado Méndez Nieto, s/n 37007, Salamanca, Spain. Phone: 34 923 294536. Fax: 34 923 294515. E-mail: asn{at}usal.es

{triangledown} Published ahead of print on 6 August 2007.

Antimicrobial Agents and Chemotherapy, October 2007, p. 3771-3774, Vol. 51, No. 10
0066-4804/07/$08.00+0     doi:10.1128/AAC.00099-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»