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Antimicrobial Agents and Chemotherapy, October 2007, p. 3771-3774, Vol. 51, No. 10
0066-4804/07/$08.00+0     doi:10.1128/AAC.00099-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Pulmonary versus Systemic Delivery of Antibiotics: Comparison of Vancomycin Dispositions in the Isolated Rat Lung{triangledown}

María José de Jesús Valle,1 Francisco González López,1 Alfonso Domínguez-Gil Hurlé,1,2 and Amparo Sánchez Navarro1*

Pharmacy Department, University of Salamanca, Licenciado Méndez Nieto, s/n 37007, Salamanca, Spain,1 University Hospital of Salamanca, Salamanca, Spain2

Received 24 January 2007/ Returned for modification 5 April 2007/ Accepted 23 July 2007

Vancomycin dispositions in the respiratory system were compared after systemic and inhalatory administration under two respiratory conditions using the isolated-lung model. Inhalatory delivery led to much higher drug levels in pulmonary tissue and fluids. The respiratory pattern affects vancomycin disposition in the pulmonary system regardless of the administration route.

* Corresponding author. Mailing address: Pharmacy Department, University of Salamanca, Licenciado Méndez Nieto, s/n 37007, Salamanca, Spain. Phone: 34 923 294536. Fax: 34 923 294515. E-mail: asn{at}usal.es

{triangledown} Published ahead of print on 6 August 2007.

Antimicrobial Agents and Chemotherapy, October 2007, p. 3771-3774, Vol. 51, No. 10
0066-4804/07/$08.00+0     doi:10.1128/AAC.00099-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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