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Antimicrobial Agents and Chemotherapy, November 2007, p. 4174-4176, Vol. 51, No. 11
0066-4804/07/$08.00+0     doi:10.1128/AAC.00917-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

A Ser678Pro Substitution in Fks1p Confers Resistance to Echinocandin Drugs in Aspergillus fumigatus{triangledown}

Eleusa Maria F. Rocha, Guillermo Garcia-Effron, Steven Park, and David S. Perlin*

Public Health Research Institute and the Department of Microbiology and Molecular Genetics, UMDNJ-New Jersey Medical School, Newark, New Jersey 07103-3535

Received 13 July 2007/ Returned for modification 21 July 2007/ Accepted 20 August 2007

An S678P substitution in Fks1p, the major subunit of glucan synthase, was sufficient to confer echinocandin resistance in Aspergillus fumigatus. The equivalent mutation in Candida spp. has been implicated in echinocandin resistance. This work demonstrates that modification of Fks1p is a conserved mechanism for echinocandin resistance in pathogenic fungi.

* Corresponding author. Mailing address: PHRI, International Center for Public Health, 225 Warren St., Newark, NJ 07103. Phone: (973) 854-3200. Fax: (973) 854-3101. E-mail: perlinds{at}umdnj.edu

{triangledown} Published ahead of print on 27 August 2007.

Antimicrobial Agents and Chemotherapy, November 2007, p. 4174-4176, Vol. 51, No. 11
0066-4804/07/$08.00+0     doi:10.1128/AAC.00917-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Katiyar, S. K., Edlind, T. D. (2009). Role for Fks1 in the Intrinsic Echinocandin Resistance of Fusarium solani as Evidenced by Hybrid Expression in Saccharomyces cerevisiae. Antimicrob. Agents Chemother. 53: 1772-1778 [Abstract] [Full Text]  
  • Arendrup, M. C., Garcia-Effron, G., Buzina, W., Mortensen, K. L., Reiter, N., Lundin, C., Jensen, H. E., Lass-Florl, C., Perlin, D. S., Bruun, B. (2009). Breakthrough Aspergillus fumigatus and Candida albicans Double Infection during Caspofungin Treatment: Laboratory Characteristics and Implication for Susceptibility Testing. Antimicrob. Agents Chemother. 53: 1185-1193 [Abstract] [Full Text]  
  • Arendrup, M. C., Perkhofer, S., Howard, S. J., Garcia-Effron, G., Vishukumar, A., Perlin, D., Lass-Florl, C. (2008). Establishing In Vitro-In Vivo Correlations for Aspergillus fumigatus: the Challenge of Azoles versus Echinocandins. Antimicrob. Agents Chemother. 52: 3504-3511 [Abstract] [Full Text]  
  • Cowen, L. E., Steinbach, W. J. (2008). Stress, Drugs, and Evolution: the Role of Cellular Signaling in Fungal Drug Resistance. Eukaryot Cell 7: 747-764 [Full Text]  


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