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Antimicrobial Agents and Chemotherapy, November 2007, p. 4184-4186, Vol. 51, No. 11
0066-4804/07/$08.00+0     doi:10.1128/AAC.00598-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

The Macrolide Resistance Genes erm(B) and mef(E) Are Carried by Tn2010 in Dual-Gene Streptococcus pneumoniae Isolates Belonging to Clonal Complex CC271{triangledown}

Maria Del Grosso,1* John G. E. Northwood,2 David J. Farrell,2 and Annalisa Pantosti1

Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy,1 GR Micro Limited, London, United Kingdom2

Received 7 May 2007/ Returned for modification 3 July 2007/ Accepted 14 August 2007

The genetic elements carrying macrolide resistance genes in Streptococcus pneumoniae isolates belonging to CC271 were investigated. The international clone Taiwan19F-14 was found to carry Tn2009, a Tn916-like transposon containing tet(M) and mef(E). The dual erm(B) mef(E) isolates carried Tn2010, which is similar to Tn2009 with the addition of a putative new transposon, the erm(B) genetic element.

* Corresponding author. Mailing address: Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Phone: (39) 0649902331. Fax: (39) 0649387112. E-mail: maria.delgrosso{at}iss.it

{triangledown} Published ahead of print on 20 August 2007.

Antimicrobial Agents and Chemotherapy, November 2007, p. 4184-4186, Vol. 51, No. 11
0066-4804/07/$08.00+0     doi:10.1128/AAC.00598-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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  • Del Grosso, M., Camilli, R., Libisch, B., Fuzi, M., Pantosti, A. (2009). New Composite Genetic Element of the Tn916 Family with Dual Macrolide Resistance Genes in a Streptococcus pneumoniae Isolate Belonging to Clonal Complex 271. Antimicrob. Agents Chemother. 53: 1293-1294 [Full Text]  
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