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Antimicrobial Agents and Chemotherapy, November 2007, p. 4196-4201, Vol. 51, No. 11
0066-4804/07/$08.00+0     doi:10.1128/AAC.00827-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Capability of 11 Antipneumococcal Antibiotics To Select for Resistance by Multistep and Single-Step Methodologies{triangledown} ,{dagger}

Catherine L. Clark, Klaudia Kosowska-Shick, Lois M. Ednie, and Peter C. Appelbaum*

Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania

Received 25 June 2007/ Returned for modification 10 July 2007/ Accepted 16 July 2007

Testing of 12 pneumococcal strains with differing resistotypes [including tet(M) positive] showed that tigecycline, amoxicillin-clavulanate, imipenem, and ceftriaxone did not select for resistant clones after 50 sequential subcultures. By comparison, azithromycin, clarithromycin, clindamycin, telithromycin, levofloxacin, moxifloxacin, and gemifloxacin did show resistant clones. Tigecycline also yielded a low frequency of resistance in single-step tests compared to all ß-lactams, macrolides/ketolides, and quinolones tested.

* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu

{triangledown} Published ahead of print on 17 September 2007.

{dagger} Supplemental material for this article may be found at http://aac.asm.org/.

Antimicrobial Agents and Chemotherapy, November 2007, p. 4196-4201, Vol. 51, No. 11
0066-4804/07/$08.00+0     doi:10.1128/AAC.00827-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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