Previous Article | Next Article 
Antimicrobial Agents and Chemotherapy, November 2007, p. 4202-4204, Vol. 51, No. 11
0066-4804/07/$08.00+0 doi:10.1128/AAC.00181-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.
In Vitro Antimycobacterial Spectrum of a Diarylquinoline ATP Synthase Inhibitor
Emma Huitric,1,2*
Peter Verhasselt,3
Koen Andries,4 and
Sven E. Hoffner1,2
Swedish Institute for Infectious Disease Control, Solna, Sweden,1
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden,2
Johnson & Johnson Pharmaceutical Research and Development, Beerse, Belgium,3
Tibotec N.V., Beerse, Belgium4
Received 7 February 2007/
Returned for modification 11 June 2007/
Accepted 13 August 2007
The diarylquinoline R207910 is in clinical development for tuberculosis treatment. The MIC50 for 41 drug-susceptible and 44 multidrug-resistant Mycobacterium tuberculosis clinical isolates was 0.032 µg/ml. Out of 20 additional mycobacterial species, three were found to be naturally resistant to R207910 and were shown to exhibit a polymorphism in their atpE genes.
* Corresponding author. Mailing address: Swedish Institute for Infectious Disease Control, Department of Bacteriology, S-171 82 Solna, Sweden. Phone: 46 8 4572473. Fax: 46 8 301797. E-mail:
emma.huitric{at}smi.ki.se
Published ahead of print on 20 August 2007.
Antimicrobial Agents and Chemotherapy, November 2007, p. 4202-4204, Vol. 51, No. 11
0066-4804/07/$08.00+0 doi:10.1128/AAC.00181-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.
This article has been cited by other articles:
-
Lounis, N., Gevers, T., Van Den Berg, J., Vranckx, L., Andries, K.
(2009). ATP Synthase Inhibition of Mycobacterium avium Is Not Bactericidal. Antimicrob. Agents Chemother.
53: 4927-4929
[Abstract]
[Full Text]
-
Diacon, A. H., Pym, A., Grobusch, M., Patientia, R., Rustomjee, R., Page-Shipp, L., Pistorius, C., Krause, R., Bogoshi, M., Churchyard, G., Venter, A., Allen, J., Palomino, J. C., De Marez, T., van Heeswijk, R. P.G., Lounis, N., Meyvisch, P., Verbeeck, J., Parys, W., de Beule, K., Andries, K., Neeley, D. F. M.
(2009). The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis. NEJM
360: 2397-2405
[Abstract]
[Full Text]
-
van den Boogaard, J., Kibiki, G. S., Kisanga, E. R., Boeree, M. J., Aarnoutse, R. E.
(2009). New Drugs against Tuberculosis: Problems, Progress, and Evaluation of Agents in Clinical Development. Antimicrob. Agents Chemother.
53: 849-862
[Full Text]
-
Haagsma, A. C., Abdillahi-Ibrahim, R., Wagner, M. J., Krab, K., Vergauwen, K., Guillemont, J., Andries, K., Lill, H., Koul, A., Bald, D.
(2009). Selectivity of TMC207 towards Mycobacterial ATP Synthase Compared with That towards the Eukaryotic Homologue. Antimicrob. Agents Chemother.
53: 1290-1292
[Abstract]
[Full Text]
-
Hong, S., Pedersen, P. L.
(2008). ATP Synthase and the Actions of Inhibitors Utilized To Study Its Roles in Human Health, Disease, and Other Scientific Areas. Microbiol. Mol. Biol. Rev.
72: 590-641
[Abstract]
[Full Text]
-
Lounis, N., Gevers, T., Van Den Berg, J., Andries, K.
(2008). Impact of the Interaction of R207910 with Rifampin on the Treatment of Tuberculosis Studied in the Mouse Model. Antimicrob. Agents Chemother.
52: 3568-3572
[Abstract]
[Full Text]