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Antimicrobial Agents and Chemotherapy, November 2007, p. 4205-4208, Vol. 51, No. 11
0066-4804/07/$08.00+0     doi:10.1128/AAC.00647-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Contributions of the Combined Effects of Topoisomerase Mutations toward Fluoroquinolone Resistance in Escherichia coli{triangledown}

Sonia K. Morgan-Linnell and Lynn Zechiedrich*

Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030-3411

Received 16 May 2007/ Returned for modification 3 July 2007/ Accepted 27 July 2007

In defined, isogenic strains, at least three mutations, two of which must be in gyrA, were required to exceed the CLSI breakpoint for fluoroquinolone resistance. Strains with double mutations in both gyrA and parC had even higher MICs of fluoroquinolones than strains with totals of three mutations.

* Corresponding author. Mailing address: Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Mail-stop BCM-280, Houston, TX 77030-3411. Phone: (713) 798-5126. Fax: (713) 798-7375. E-mail: elz{at}bcm.edu

{triangledown} Published ahead of print on 6 August 2007.

Antimicrobial Agents and Chemotherapy, November 2007, p. 4205-4208, Vol. 51, No. 11
0066-4804/07/$08.00+0     doi:10.1128/AAC.00647-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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