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Antimicrobial Agents and Chemotherapy, November 2007, p. 4211-4213, Vol. 51, No. 11
0066-4804/07/$08.00+0     doi:10.1128/AAC.01087-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Penetration of Amphotericin B Lipid Formulations into Pleural Effusion{triangledown}

Stefan Weiler,1 Rosa Bellmann-Weiler,2 Michael Joannidis,3 and Romuald Bellmann1,3*

Clinical Pharmacokinetics Unit, Inflammation Research Laboratory,1 Infectious Diseases Unit,2 Medical Intensive Care Unit, Division of General Internal Medicine, Department of Internal Medicine, Innsbruck Medical School, Innsbruck, Austria3

Received 18 August 2007/ Returned for modification 22 August 2007/ Accepted 24 August 2007

The penetration of the amphotericin B (AMB) lipid formulations (liposomal AMB, AMB colloidal dispersion, and AMB lipid complex formulations) into pleural effusions in seven critically ill patients was assessed. AMB was detected in all pleural effusion samples at concentrations ranging from 0.02 to 0.43 µg/ml. The penetration ratio was 3 to 44%.

* Corresponding author. Mailing address: Division of General Internal Medicine, Department of Internal Medicine, Innsbruck Medical School, Anichstrasse 35, A-6020 Innsbruck, Austria. Phone: 43 512 504 81389. Fax: 43 512 504 24199. E-mail: romuald.bellmann{at}i-med.ac.at

{triangledown} Published ahead of print on 4 September 2007.

Antimicrobial Agents and Chemotherapy, November 2007, p. 4211-4213, Vol. 51, No. 11
0066-4804/07/$08.00+0     doi:10.1128/AAC.01087-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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