This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schroeder, S. J.
Right arrow Articles by Moore, P. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schroeder, S. J.
Right arrow Articles by Moore, P. B.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, December 2007, p. 4462-4465, Vol. 51, No. 12
0066-4804/07/$08.00+0     doi:10.1128/AAC.00455-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Negamycin Binds to the Wall of the Nascent Chain Exit Tunnel of the 50S Ribosomal Subunit{triangledown}

Susan J. Schroeder,1,{dagger},{ddagger} Gregor Blaha,2,3,{dagger} and Peter B. Moore1,2*

Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107,1 Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520-8024,2 Howard Hughes Medical Institute, New Haven, Connecticut 06520-81143

Received 3 April 2007/ Returned for modification 15 June 2007/ Accepted 24 July 2007

Negamycin, a small-molecule inhibitor of protein synthesis, binds the Haloarcula marismortui 50S ribosomal subunit at a single site formed by highly conserved RNA nucleotides near the cytosolic end of the nascent chain exit tunnel. The mechanism of antibiotic action and the function of this unexplored tunnel region remain intriguingly elusive.

* Corresponding author. Mailing address: 225 Prospect Street, P.O. Box 208107, New Haven, CT 06520-8107. Phone: (203) 432-3995. Fax: (203) 432-5781. E-mail: peter.moore{at}yale.edu

{triangledown} Published ahead of print on 30 July 2007.

{dagger} These two authors contributed equally to this work.

{ddagger} Present address: Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019-3051.

Antimicrobial Agents and Chemotherapy, December 2007, p. 4462-4465, Vol. 51, No. 12
0066-4804/07/$08.00+0     doi:10.1128/AAC.00455-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»