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Antimicrobial Agents and Chemotherapy, December 2007, p. 4471-4473, Vol. 51, No. 12
0066-4804/07/$08.00+0     doi:10.1128/AAC.00373-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Effect of Antimicrobial Compounds on Balamuthia mandrillaris Encystment and Human Brain Microvascular Endothelial Cell Cytopathogenicity{triangledown}

Ruqaiyyah Siddiqui,1 Abdul Matin,1 David Warhurst,2 Monique Stins,3 and Naveed Ahmed Khan1*

School of Biological and Chemical Sciences, Birkbeck College,1 London School of Hygiene and Tropical Medicine, University of London, London, England, United Kingdom,2 Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland3

Received 20 March 2007/ Returned for modification 20 June 2007/ Accepted 9 September 2007

Cycloheximide, ketoconazole, or preexposure of organisms to cytochalasin D prevented Balamuthia mandrillaris-associated cytopathogenicity in human brain microvascular endothelial cells, which constitute the blood-brain barrier. In an assay for inhibition of cyst production, these three agents prevented the production of cysts, suggesting that the biosynthesis of proteins and ergosterol and the polymerization of actin are important in cytopathogenicity and encystment.

* Corresponding author. Mailing address: School of Biological and Chemical Sciences, Birkbeck College, University of London, London WC1E 7HX, England, United Kingdom. Phone: 44-(0)207-079-0797. Fax: 44-(0)207-631-6246. E-mail: n.khan{at}sbc.bbk.ac.uk

{triangledown} Published ahead of print on 17 September 2007.

Antimicrobial Agents and Chemotherapy, December 2007, p. 4471-4473, Vol. 51, No. 12
0066-4804/07/$08.00+0     doi:10.1128/AAC.00373-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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