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Antimicrobial Agents and Chemotherapy, December 2007, p. 4474-4476, Vol. 51, No. 12
0066-4804/07/$08.00+0     doi:10.1128/AAC.00880-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

In Vitro Study of Candida tropicalis Isolates Exhibiting Paradoxical Growth in the Presence of High Concentrations of Caspofungin{triangledown}

G. Sóczó,1 G. Kardos,1 I. Varga,2 B. Kelentey,2 R. Gesztelyi,3 and L. Majoros1*

Department of Medical Microbiology, Medical and Health Science Center, University of Debrecen, Hungary,1 Faculty of Dentistry, Medical and Health Science Center, University of Debrecen, Hungary,2 Department of Pharmacology and Pharmacodynamics, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary3

Received 5 July 2007/ Returned for modification 29 July 2007/ Accepted 27 September 2007

Paradoxical growth was noted in RPMI 1640 and antibiotic medium 3 in the case of 14 and 1 of 15 Candida tropicalis strains, respectively, at a caspofungin concentration of 12.5 µg/ml using minimum fungicidal concentration tests. Time-kill assays showed that against isolates killed at lower concentrations, caspofungin at a concentration of 12.5 µg/ml was only fungistatic.

* Corresponding author. Mailing address: Department of Medical Microbiology, University of Debrecen, 4032 Debrecen, Nagyerdei krt. 98., Hungary. Phone: 36-52-417-565. Fax: 36-52-417-565. E-mail: major{at}dote.hu

{triangledown} Published ahead of print on 8 October 2007.

Antimicrobial Agents and Chemotherapy, December 2007, p. 4474-4476, Vol. 51, No. 12
0066-4804/07/$08.00+0     doi:10.1128/AAC.00880-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Varga, I., Soczo, G., Kardos, G., Majoros, L. (2008). Time-kill studies investigating the killing activity of caspofungin against Candida dubliniensis: comparing RPMI-1640 and antibiotic medium 3. J Antimicrob Chemother 62: 149-152 [Abstract] [Full Text]  


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