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Antimicrobial Agents and Chemotherapy, December 2007, p. 4477-4479, Vol. 51, No. 12
0066-4804/07/$08.00+0     doi:10.1128/AAC.00529-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Pharmacodynamics of Doxycycline in a Murine Malaria Model{triangledown}

Kevin T. Batty,1* Angela S. F. Law,1 Verity Stirling,2 and Brioni R. Moore1

School of Pharmacy, Curtin University of Technology, Bentley, Western Australia,1 School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia2

Received 21 April 2007/ Returned for modification 27 July 2007/ Accepted 2 September 2007

Doxycycline is reported to impair second-generation parasite schizogony. The effects of doxycycline alone and combined with dihydroartemisinin were investigated in a murine malaria model. Doxycycline lowered the rate of parasite growth within 2 days, with maximum effect in 6 days. Addition of dihydroartemisinin led to an additive antimalarial effect.

* Corresponding author. Mailing address: School of Pharmacy, Curtin University of Technology, GPO Box U1987, Perth, 6845 Western Australia, Australia. Phone: (61-8) 9266 7369. Fax: (61-8) 9266 2769. E-mail: Kevin.Batty{at}curtin.edu.au

{triangledown} Published ahead of print on 17 September 2007.

Antimicrobial Agents and Chemotherapy, December 2007, p. 4477-4479, Vol. 51, No. 12
0066-4804/07/$08.00+0     doi:10.1128/AAC.00529-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Moore, B. R., Ilett, K. F., Page-Sharp, M., Jago, J. D., Batty, K. T. (2009). Piperaquine Pharmacodynamics and Parasite Viability in a Murine Malaria Model. Antimicrob. Agents Chemother. 53: 2707-2713 [Abstract] [Full Text]  


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