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Antimicrobial Agents and Chemotherapy, December 2007, p. 4484-4485, Vol. 51, No. 12
0066-4804/07/$08.00+0     doi:10.1128/AAC.00708-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Intrinsic Novobiocin Resistance in Staphylococcus saprophyticus{triangledown}

Anna A. Vickers, Ian Chopra, and Alex J. O'Neill*

Antimicrobial Research Centre and Research Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom

Received 31 May 2007/ Returned for modification 24 July 2007/ Accepted 5 September 2007

Intrinsic novobiocin resistance in Staphylococcus saprophyticus was associated with expression of a novobiocin-resistant form of the drug target protein (GyrB). Site-directed mutagenesis established that resistance depends upon the presence of two specific amino acid residues in GyrB: a glycine at position 85 and a lysine at position 140.

* Corresponding author. Mailing address: Antimicrobial Research Centre and Research Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom. Phone: 44-113-343-5600. Fax: 44-113-343-5638. E-mail: A.J.O'Neill{at}leeds.ac.uk

{triangledown} Published ahead of print on 17 September 2007.

Antimicrobial Agents and Chemotherapy, December 2007, p. 4484-4485, Vol. 51, No. 12
0066-4804/07/$08.00+0     doi:10.1128/AAC.00708-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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