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Antimicrobial Agents and Chemotherapy, December 2007, p. 4492-4494, Vol. 51, No. 12
0066-4804/07/$08.00+0     doi:10.1128/AAC.00843-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

BK Virus Replication In Vitro: Limited Effect of Drugs Interfering with Viral Uptake and Intracellular Transport{triangledown}

Parmjeet Randhawa,* Noush Afarin Farasati, and Yuchen Huang

Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh Medical Center, UPMC Montefiore Hospital, Room E733, Pittsburgh, PA 15213

Received 28 June 2007/ Returned for modification 9 August 2007/ Accepted 11 September 2007

BK virus is an important pathogen in kidney transplant recipients. In vitro studies demonstrated slight antiviral activity for chloroquine and nystatin. A sialic acid derivative, BTB11968, was identified as a lead compound for further development.

* Corresponding author. Mailing address: Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh, Room E737, UPMC-Montefiore Hospital, 3459 Fifth Ave., Pittsburgh, PA 15213. Phone: (412) 647-7646. Fax: (412) 647-5237. E-mail: randhawapa{at}upmc.edu

{triangledown} Published ahead of print on 24 September 2007.

Antimicrobial Agents and Chemotherapy, December 2007, p. 4492-4494, Vol. 51, No. 12
0066-4804/07/$08.00+0     doi:10.1128/AAC.00843-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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